ea0014pl5 | The coordination of circadian time in brain and peripheral organs | ECE2007
Schibler Ueli
, Kornmann Benoit
, Saini Camille
, Reinke Hans
, Schaad Olivier
, Dibner Charna
The mammalian circadian timing system influences most physiology, including sleep-wake cycles, cardiovascular activity, body temperature, renal plasma flow, intestinal peristaltic, metabolism, xenobiotic detoxification, and many endocrine functions. Circadian pacemakers were originally believed to exist only in a few specialized cell types, such as neurons of the suprachiasmatic nucleus (SCN). However, this view has been challenged by the discovery that self-sustained and cell...