Endocrine Abstracts

Objective: Fetal hyperinsulinemia correlated with large birth weight and impaired glucose tolerance test and obesity in second decades of life. In study we compared the correlation between Fetal Insulin production (as estimated by amniotic fluid (AF) C-peptide concentration) and AF Insulin with macrosomia (as estimated by neonatal birth weight >4000 gr).

Methods: Thirty eight neonates was studied: Ten infants were macrosomia and twenty eight was normal (birth weight <4000 gr). Amniontic Fluid C-peptide and Insulin concentration of mother and fetal blood C-peptide and Insulin was measured during delivery with radio immuno assay and mother and fetal glucose was measured at the same time and correlated with neonatal macrosomia within 1 hours of birth.

Results: There was a significant correlation between infant serum C-peptide level and macrosomia. Amniotic Fluid Insulin level is higher in a group of macrosomic infant but this correlation is not significant perhaps due to secretion of placental insulinase. AF C-peptide was higher in group of macrosomia.Also there was a significant correlation between maternal serum C-peptide and macrosomia.Infant and mother serum insulin is higher in a group of macrosomia.

Conclusion: Our results suggest that Fetal Insulin (as estimated by AF C- peptide) and maternal serum Insulin and C- peptide production, can influence fetal weight and induced fetal macrosomia.