Endocrine Abstracts

Thyroid hormone is critically important for many developmental processes. However, less is known about how this hormone elicits its actions, a question that becomes more puzzling given that that distinct target tissues respond in different ways and often at different times. How does this systemic hormonal signal elicit its diverse responses? Targeted mutagenesis of thyroid hormone receptors (TR) encoded by the Thrb and Thra genes has indicated that some specifici...

D Forrest, National Institutes of Health, NIDDK, Bethesda, Md 20892, United States. AbstractDr Forrest studies the role of thyroid hormone in development. He is particularly interested in the genes that mediate these functions, including those encoding thyroid hormone receptors and deiodinase enzymes. Recent findings have revealed novel functions for these genes in sensory systems.Dr Forrest is a...