Endocrine Abstracts

It is a widely held view that genetic mutations cause diseases by interfering with the normal function of the protein encoded by the gene in question, and there are many examples of this phenomenon. However it is increasingly apparent that in some cases mutant proteins have altered function because they have failed to assemble correctly, or because they fail to reach the correct compartment of the cell correctly. Recent work investigating certain inherited disorders of the adr...

Adrian Clark, Barts & the London, QMUL, London, United Kingdom. AbstractAdrian Clark graduated in Medicine from St Bartholomew’s Hospital Medical College in 1976. After several junior medical training posts at Barts, Nottingham, Hammersmith and Guys, he spent two years at the NCI in Bethesda working on the cloning of the EGF receptor with Ira Pastan, then later moved to work for three years with Kevin Catt, al...