Endocrine Abstracts

Estrogen Receptor (ER) regulation of target gene transcription is a significant factor in tumor development and progression. Previous work on ER-mediated transcription focused primarily on promoter regions of target genes, although recent work from our lab combining ER Chromatin Immunoprecipitation (ChIP) with tiled microarrays covering chromosomes 21 and 22, showed that distal enhancers appear to be the primary ER binding sites, and that these sites require the Forkhead prote...

In response to hormone activation of the glucocorticoid receptor, GR responsive promoters move through a complex series of activity states, a phenomenon we term promoter progression. Genome-wide profiling of glucocorticoid receptor (GR) regulated loci reveals several classes of response, including genes that are transiently activated and genes that are transiently repressed. In contrast to the conventional paradigm of activation and repression, GR modulation of genome function...