Endocrine Abstracts

Introduction: The thyroid is a multifunctional endocrine gland which, by its hormones, affects all the organs, metabolisms and nonspecific defence of the body. The aim of this study is to establish if endogenous thyroxin (FT₄) is involved in the nonspecific defence of the organism.

Material and methods: 94 patients were included in the study, 47 with hyperthyroidism and 47 with hypothyroidism, 81 women, 13 men aged 7–78. FT₄ was determined by ECLIA and IgM, IgG, IgA by nephelometry.

Results: We noticed a reversed relation between FT₄ and IgM in patients with hyperthyroidism and hypothyroidism irrespective of age and sex. We found IgG results almost identical in both forms of dysthyreosis. IgA oscilates within normal limits irrespective of sex, age, kind of dysthyroidism.

Conclusions: IgM concentration is significantly higher in hypothyroid patients than in the hyperthyroid ones. This reversed relation is more evident in hypothyroid women. In our research the anabolic effect of FT₄ is evident. The decrease of FT₄ determines the increase of IgM level. From this point of view hypothyroidism can be regarded of benefical state for the body. Within the research groups the IgG normal values appear higher or lower in almost identical percentage. The conclusion is that this proteic fraction with in important part in the nonspecific defence is not sensitive to the thyroxin action in any concentration and it is not modified in dysthyreosis. IgA isn’t sensitive either to the action of endogenous thyroxin.

References

1. László Annamária et al. Implicatiile hormonilor tiroidieni în apărarea nespecifică a organismului Rev Med Farm Tg.-Mureş 2000, 45/1–4, 83–89; 2.

2. Manzolii S et al. Allergic airway inflammation in hypothyroid rats J Allerg Clin Immunol USA 1999, 104/3, 595–600.