Searchable abstracts of presentations at key conferences in endocrinology
Endocrine Abstracts (2006) 11 P697

ECE2006 Poster Presentations Reproduction (80 abstracts)

A review of cimetidine (tagamet) effects as a reoproductive toxicant in male rats leydig cells

Erfan Eilati


Urmia Azad Islamic University, Urmia, West Azarbayjan, Iran.


Cimetidine is a selective antagonist of histamine at gastric H2-receptor sites. A 24 month oral cimetidine toxicity and carcinogenicity study in rats at dose levels of 150, 378 and 950 mg/kg was performed. Cimetidine appeared to produce changes involving the liver and the male reproductive organs. In this paper non-tumour Leydig cell morphology was normal in cimetidine treated groups. It was concluded that the higher statistically significant incidence (apparent only in aged rats) of benign Leydig cell tumours seen in cimetidine treated groups compared to controls probably represented a chance occurrence and did not imply a tumorigenic risk for man.

Volume 11

8th European Congress of Endocrinology incorporating the British Endocrine Societies

European Society of Endocrinology 
British Endocrine Societies 

Browse other volumes

Article tools

My recent searches

No recent searches.