ECE2006 Poster Presentations Neuroendocrinology and behaviour (70 abstracts)
Effect of gastric bypass and gastric banding on neurotensin levels in morbidly obese patients
M Christ-Crain 1 , R Stoeckli 1 , A Ernst 2 , N Morgenthaler 2 , S Bilz 1 , M Korbonits 3 , A Bergmann 2 , B Mueller 1 & U Keller 1
1Dept. of Endocrinology, University Hospital, Basel, Switzerland; 2Research Dept., BRAHMS AG, Berlin, Germany; 3Dept. of Endocrinology, St. Bartholomews Hospital, London, United Kingdom.
Objective: Neurotensin is an anorexigenic peptide produced mainly in the N-cells of the ileum; levels are decreased in obese subjects and increase after bariatric surgery. This study is the first to compare the baseline and postoperative levels of neurotensin in patients after gastric bypass, gastric banding, and non-operated controls, respectively, during long-term follow-up.
Patients and Methods: Overnight fasting plasma neurotensin levels were measured with a new sandwich immunoassay in morbidly obese subjects at baseline and 3, 6, 12 and 24 months after Roux-en-Y gastric bypass (n=5, mean (SD) body mass index (BMI) 44±2), gastric banding (n=8, BMI 42±1), and in non-operated controls (n=7, BMI 41±1).
Results: After gastric bypass and banding, mean (SD) body weight decreased by 29.5±5.5 kg and 22.8±5.9 kg respectively, with no change in non-operated controls. The decrease after 3 and 6 months was more pronounced after gastric bypass as compared to gastric banding (P<0.05). Plasma neurotensin levels in patients after gastric bypass increased from 24.8±19.6 at admission to 87.0±60.3 after 6 months and 75.2±48.3 U/ml after 24 months (P=0.004, repeated measures ANOVA). In contrast, in patients with gastric banding, neurotensin levels remained stable (20.8±6.1 at admission, 22.0±13.3 after 6 months, 22.8±11.7 U/ml after 24 months, P=ns). Neurotensin levels did not change in non-operated controls. There was no correlation of neurotensin levels with plasma ghrelin or leptin levels.
Conclusion: Plasma neurotensin levels show a significantly more pronounced increase after gastric bypass as compared to gastric banding. This could be an additional explanation for the more pronounced decrease in appetite and weight in patients with gastric bypass.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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