Endocrine Abstracts

Considering the high incidence of diabetes mellitus in society and related therapeutic problem, we investigated antihyperlipidemic effects of alcoholic extracts of Juglans regia septum on serum tryglycerids, cholesterol, LDL and HDL in streptozocin-induced diabetic adult male rats. In present study, alcoholic extract of septum of juglans regia linn. Was found to have potent antihyperlipidemic activity. supplementation of this alcoholic extract by gavage at dose of 0.1, 0.2 and 0.5 g/kg at 0.5 ml distilled water in diabetic rats result a significant diminution of fasting blood glucose and tryglycerids and and increase LDL level after 14 days. Continuous supplementation of this extract for 14 days result no significant difference in serum insulin, cholesterol and HDL in diabetic rats. Elevated levels of of serom aminotransaminase enzymes (AST and ALT) were reported in animals treated with toxic plant derived products. Activities of serum aminotransaminase enzymes alanine aminotransferase (ALT) and aspartate aminotransferase (AST), were decreased significantly in the alcoholic extract supplemented group in respect to control group.