Searchable abstracts of presentations at key conferences in endocrinology
Endocrine Abstracts (2006) 11 P363

Wroclaw Medical University, Wroclaw, Poland.


Introduction: Trisomy 21 is often associated with congenital malformation and metabolic abnormalities such as glucose intolerance and an increased risk of developing diabetes mellitus.

Aim: The aim of this study was to assess carbohydrate metabolism in children with Down syndrome.

Material and methods: Thirty nine children with Down syndrome, aged between 2 months and 16 years (mean 6.5 years), took part in the study. Glycaemia before and after a standard meal, cholesterol, HDL- cholesterol, LDL-cholesterol, triglycerides and thyroid hormones were measured. The children were divided into two groups: below and above 2 years of age (ZD-1; n=12, ZD-2; n=19 respectively). We excluded 7 children with glucose intolerance and 1 child with diabetes mellitus type I from statistical analysis. The Ethics Committee of Wroclaw Medical University approved of the study protocol.

Results: In both groups flat glucose curves after meal ingestion were observed. No significant differences were found in glucose concentration levels between the two groups. The mean glucose levels measured in mg% (0′, 30′, 60′, 90′, 120′) in ZD-1 group were: 82,83; 82,58; 88,58; 81,33; 85,71; 81,79; and in ZD-2 group: 83,79; 89,91; 94,83; 93,16; 92,26; 89,90. In both groups a negative correlation was found between fasting glucose concentration and TSH concentration (ZD-1: r=−0.58, ZD-2: r=−0.30) and a positive correlation between glucose and TG concentration (ZD-1: in 30′ r=0.53; ZD-2: in 120′: r=0.31). The results enabled to make the diagnosis of glucose intolerance in seven children and of diabetes mellitus in one child.

Conclusions: Due to the apparent abnormalities, carbohydrate metabolism should be closely and regularly monitored in children with Down syndrome.

Volume 11

8th European Congress of Endocrinology incorporating the British Endocrine Societies

European Society of Endocrinology 
British Endocrine Societies 

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