ECE2006 Poster Presentations Clinical case reports (128 abstracts)
A complex case of pregnancy and pegvisamont treated acromegaly
AI Qureshi , G Ramanathan , A Walton , L Seal , G Bano , I Manyonda & A Panahloo
St George’s University of London, London, United Kingdom.
A 29-year-old woman with polycystic ovary syndrome was diagnosed with acromegaly having presented with a two year history of secondary amenorrhea, a change in physical appearance and sweating. The diagnosis was confirmed with an oral glucose tolerance test that also demonstrated she had impaired glucose tolerance. Radiological imaging demonstrated a 2.2 cm pituitary tumor that was compressing the optic chiasm and a bi-temporal visual field defect was confirmed on Goldman fields.
Over a 4 year period she underwent four neurosurgical operations and received 53 Gy radiotherapy but failed to ever achieve biochemical cure. Whist on a somatostatin analogue her acromegaly remained active and in 2004 she was commenced on pegvisamont, a growth hormone antagonist. The latter was discontinued when she conceived after her first cycle of IVF. During her pregnancy she developed gestational diabetes requiring insulin therapy and pituitary gland enlargement was accompanied by deterioration in her visual fields. The patient was, however, treated conservatively and an elective cesarean section was performed at 37 weeks gestation. A healthy boy was delivered in July 2005 and remains developmentally normal.
In summary this is a complex case with an array of medical problems that required intricate care by a multi-disciplinary team and to our knowledge represents the first human pregnancy conceived on pegvisamont therapy for active acromegaly.
Article tools
My recent searches
My recently viewed abstracts
Authors
Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
© Bioscientifica 2024 |
Privacy policy |
Cookie settings
BiosciAbstracts
Bioscientifica Abstracts is the gateway to a series of products that provide a permanent, citable record of abstracts for biomedical and life science conferences.
Find out more