ECE2006 Poster Presentations Thyroid (174 abstracts)
Rate of decrease in antithyroid antibody levels after therapeutic intervention in patients with thyroid cancer
D Thomas 1 , I Kostoglou-Athanassiou 1 , E Vassiliou 1 , V Liakos 1 , N Mytakidis 1 , F Chatzimarkou 1 , P Athanassiou 2 & Ph Kaldrymidis 1
1Metaxa Hospital, Pireaus, Greece; 2Asclepeion Hospital, Athens, Greece.
The detection of antithyroid antibodies, specifically of antithyroglobulin antibodies, in patients with differentiated thyroid carcinoma after near-total thyroidectomy, radioiodine therapy and thyroxine suppression presents difficulties in screening patients for residual disease or recurrence of the disease as it may interfere with thyroglobulin measurement. The aim of the study was to estimate the rate of decrease in antithyroid antibody levels in patients with differentiated thyroid carcinoma after near-total thyroidectomy, 131I therapy and thyroxine suppression.
Patients with differentiated thyroid carcinoma, n=75, age at diagnosis 47.1±13.7 years (mean±sd), median 48 years, were studied. The patients had differentiated thyroid carcinoma and they had been managed by near total thyroidectomy, 131I therapy and thyroxine suppression. Before surgery they had abnormally elevated antithyroid [antimicrosomal (anti-TPO) and antithyroglobulin (anti-Tg)] antidody levels. Recording of antithyroid antibody levels was performed at least 9 months after 131I therapy and until 192 months later.
Anti-TPO antibodies. In 50% of the patients with abnormally elevated levels of anti-TPO antibodies before surgery normal values of the respective antibodies were observed 75 months after surgery and 131I administration. The decrease in anti-TPO levels was not correlated with sex, age at diagnosis, histology and size of the tumor. Anti-Tg antibodies. In 50% of the patients with abnormally elevated levels of anti-Tg antibodies before surgery normal levels of the respective antibodies were observed 41 months after surgery and 131I administration. The decrease in anti-Tg levels was not correlated with sex, age at diagnosis, histology and size of the tumor. Anti-Tg antibody levels decreased to normal earlier than anti-TPO levels (P<0.05).
Anti-TPO and anti-Tg antibodies remain detectable a long time after complete destruction of thyroid tissue. Anti-Tg antibody levels seem to decrease earlier than anti-TPO levels.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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