Endocrine Abstracts

Introduction: Salt is an essential compound to provide Na, but over-consumption of salt could be lethal. As using high salt solution is a traditional way of committing suicide in china, In this research, the action of to salt sensation during consumption of salt solution is elevated.

Method: 6 groups, each containing 10 male rat with 200 gr weight were selected. 5 concentration of salt in distilled water were prepared (1,3,5,7,9%). During this study, rats were deprived of potable water and above salt solution were given to rats. Control group used tap water of Zanjan.

Results: Water consumption on 1,3% groups as compared to control group increased 81% and 44%, but for 5, 7 and 9% group as compared with control group was decreased 56, 73 and 85%.

Discussion: 1%, 3% salt solution could not decrease Na serum level and thirst quench and because taste protective mechanism dose not act strongly, salt solution consumption increased in this concentration, but when animal were used 5, 7, 9% salt solution, the kidney have to use some of body water along with salt solution to be able to excrete the excessive solute load and with a positive feedback loop, this phenomena can lead to the immediate death of animal die. Animal refusal from drinking highly concentrated salt solution is related to taste protective mechanism.