Endocrine Abstracts

Background: Diabetic nephropathy is leading cause of end-stage renal disease (ESRD), which requires dialysis or a transplant. Progression of diabetic nephropathy (DN) leads to development of chronic renal failure (CRF).

Material and methods: Data for 124 554 DM patients who live in Moscow region (MR) is in the MR DM register for 2004. The number of T1D- 8747, T2D patients is 115, 534. These registers only contain information about registered cases of DN.

Results: Registered prevalence of DN when there is T1D is 21.7%, and 6.9% when there is T2D. The prevalence of DN when there is T1D is bit higher among men, and among women when there is T2D. When children have T1D it makes up 4.3%, 13.1% among adolescents, and 23.9% among adults. Percent of DN reaches its maximum when there has been long-term diabetes for over 15 years: 40.8% when there is T1D, and 15.4% for T2D, and also when there is an increase in the severity of disease, making up 21.1% given a severe form.

Prevalence of CRF among T1D patients is 0.65%, and 0.2% for T2D. Dialysis gets 60 patients, which makes up 0.6% of DM patients with DN. Among them 45.0% are hemodialysis, 53,3% are peritoneal dialysis. 1 patient gets renal transplantation. The duration of peritoneal dialysis among DM patients varies from 2 to 78 months. DM patients make up 13.5% of all patients who receive dialysis (8.9% are on hemodialysis, 22.5% are on peritoneal dialysis). DM patients on peritoneal dialysis make up 21.2% of overall number of CRF patients.

Conclusion: Diagnosis of diabetic nephropathy in irreversible stage and large number of severe forms requires prophylactic measures.