ECE2006 Poster Presentations Diabetes, metabolism and cardiovascular (174 abstracts)
Metabolic syndrome and insulin sensitivity in early glycoregulation disorders
VDS Vesna Dimitrijevic-Sreckovic 1 , PDJ Predrag Djordjevic 1 , SP Srdjan Popovic 1 , DG Drasko Gostiljac 1 , FC Fadil Canovic 1 , BS Branko Sreckovic 3 , MI Miroljub Ilic 1 , TN Tanja Novakovic 1 , EC Emina Colak 2 , RO Radmila Obrenovic 2 , GM Gordana Milic 1 , TN Tanja Nisic 1 & VP Visnja Panasiuk 1
1Institute for Endocrinology, Diabetes and Metabolic Diseases, Clinical Center of Serbia, Belgrade, Serbia, Serbia and Montenegro; 2Institute of Medical Biochemistry, Clinical Center of Serbia, Belgrade, Serbia, Serbia and Montenegro; 3Institute of Cardiovascular Diseases, Clinical Center of Serbia, Belgrade, Serbia, Serbia and Montenegro.
Background and Aims: Early glycoregulation disorders, impaired fasting glucose (IFG) and impaired glucose tolerance (IGT) are associated with metabolic syndrome (MS). The aim of this study is: (a) to analyze parameters of insulin sensitivity, glycoregulation, lipid status, microalbuminuria (MI) and homocysteine (HCY) in patients with obesity (I), IFG (II), IGT (III) and newly diagnosed DM type 2 (IV) patients; (b) to determine the percentage of metabolic syndrome at these patients.
Materials and Methods: The study included 148 obese individuals (BMI>25 kg/m2) over 45 years. The oral glucose tolerance test (OGTT)- WHO, WG, 1998, revealed obesity in 23.6%, IFG in 12.2%, IGT in 35.8%, diabetes mellitus type 2 (DM2) in 28.4% of patients. Insulin sensitivity was determined by HOMA IR; lipid status was determined by spectrophotometry (total cholesterol, HDL-cholesterol, LDL-cholesterol, triglycerides) and immunochemical method Lp(a)1.
Results: The metabolic syndrome accounted for 38.2% in obese patients, while it was almost double in other groups (IFG - 72.2%, IGT - 76.0%, DM2 - 70.7%). BMI indicated extreme obesity in all groups. HOMA IR was elevated in IGT and DM2 groups. LDL/HDL ratio was at the upper maximum level and did not differ statistically between groups. Lp(a) was slightly increased in IGT patients and considerably increased in IFG ones. Blood pressure was moderately increased in all groups of patients, with no statistical difference between groups. Homocystein was at upper maximum level (11.7±3.0, 12.3±4.6, 12.3±4.6 μmol/l) and there was no important statistical difference between groups. MI showed a statistical importance (P<0.05) at obese patients with MS compared to those without MS.
Conclusions: Results obtained indicate that a metabolic syndrome exists at two thirds of patients with early glycoregulation disorders (IFG, IGT) and newly diagnosed diabetes mellitus type 2, and that it is associated with decreased insulin sensitivity, hypertension and hyperlipoproteinemia.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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