Endocrine Abstracts

The aim of the study was to estimate the parameters of lipid metabolism (total cholesterol – TC, LDL and HDL cholesterol and triglycerides – TG) in women with GDM. Material and method. The study was carried out in 121 GDM women being at the age of 30.5±5.7. The control group (CG) were 36 healthy women at the age of 25.3±4.4. Results. The parameters were analyzed while making diabetes mellitus diagnosis in GDM women at the end of the second gestational trimester in CG and at the end of the third trimester in both groups. During pregnancy period the improvement of glicemic control was observed, which was demonstrated by a statistically significant decrease of fasting blood glucose (FBG), of mean blood glucose and a fructosamin level in blood. No significant of an improvement of HbA_1c value was found. At the end of gestation period a significant increase of TG level was observed in the patients with GDM while a considerable increase of TG and TC was found in the control group. In the third trimester of pregnancy the TC level was significantly higher in CG than in GDM patients. In the GDM group a considerably lower HDL level was observed in the first trimester in women suffering from obesity before pregnancy, and significantly lower TC and LDL levels were found in the third pregnancy trimester in the same group of women. There were no significant TG value differences between the groups of pregnant women being in the first and in the third trimester. However, the TG values in overweight women before pregnancy at the moment of making a GDM diagnosis were significantly higher than in those non-obese women. Conclusion. It was proved that in the GDM group the changes in the lipid levels were lower than the changes in the control group. It is worth noticing that the GDM obese patients before pregnancy showed lower lipoprotein values than healthy, obese or non obese patients. This can result from the influence of more rigorous diet treatment and from more frequent insulin therapy in the GDM group of patients.