ECE2006 Poster Presentations Comparative endocrinology (7 abstracts)
The patients with HIV lipodystrophy syndrome have lower total fat mass but similar free fat mass
P Freitas 1 , D Carvalho 1 , F Correia 1 , T Faria 2 , B Perez 2 , R Marques 3 , R Serrão 3 , J Pereira 2 , A Mota Miranda 3 & JL Medina 1
1Endocrinology Department, Hospital S. João, Porto, Portugal; 2Nuclear Medicine, Hospital S. João, Porto, Portugal; 3Infectious Disease Department, Hospital S. João, Porto, Portugal; 4University of Porto Medical School, Porto, Portugal.
Introduction: The highly active antiretroviral therapy (HAART) completely changed the natural history and body composition of the infected patients. The lipodystrophy syndrome of HIV-infected patients (IP) is characterized by fat mass redistribution in the limbs, face lipoatrophy and abdominal lipohypertrophy. Dual-energy x-ray absorptiometry scan (DEXA) and bioelectrical impedance (BIA) are techniques to determine body composition (BC).
Aims: Evaluate the BC in HIV-IP treated with HAART with (CL) and without clinical lipodystrophy (WCL).
Patients and methods: We studied 117 HIV-IP, 25 women and 92 men, by anthropometry, BIA (Tanita) and DEXA.
| CL (n=82) | WCL (n=35) | P | |
| Age (years) | 48.8±10.9 | 40.4±10.1 | <0.001 |
| Duration of disease (years) | 8.6±4.1 | 6.5±3.3 | <0.05 |
| Duration of treatment HAART (years) | 7.7±4.0 | 4.8±3.2 | <0.005 |
| BMI (Kg/m2) | 24.4±3.8 | 25.9±4.9 | <0.05 |
| Waist circumference (WC) (cm) | 90.2±10.2 | 92.6±13.2 | ns |
| Hip circumference (HC) (cm) | 91.9±7.1 | 99.0±8.4 | <0.001 |
| Thigh circumference (TC) (cm) | 46.3±4.8 | 50.4±5.8 | <0.001 |
| Total Fat Mass (TFM) (%) (BIA) (n=117) | 18.8±7.6 | 24.3±10.7 | <0.05 |
| Total Fat Mass (TFM) (%) (DEXA) (n=83) | 15.2±8.9 | 27.2±10.8 | <0.001 |
| Fat Free Mass (FFM) (Kg) (BIA) (n=117) | 53.3±7.4 | 53.4±8.6 | ns |
| Fat Free Mass (FFM) (Kg) (DEXA) (n=83) | 51.2±7.2 | 50.6±9.3 | ns |
| Total Body Water (Kg) (BIA) (n=117) | 39.0±5.4 | 39.1±6.3 | ns |
| To compare the variables we used Mann-Whitney test. | |||
Results: The patients with CL had similar WC to WCL but lower HC and TC. In patients with CL we observed a % TFM significantly lower (BIA and DEXA) but similar FFM and TBW.
Conclusions: The patients with HIV-Lipodystrophy Syndrome had WC, FFM and TBW similar to the patients WCL. The TFM of the same patients is significantly reduced.
Volume 11
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