ea0011s8 | Vitamin D action | ECE2006
Bouillon R
Ligand activated VDR regulates about 3% the mouse genome. Its classical function is to regulate calcium and bone homeostasis. 1,25-(OH)2D is essential for transepithelial calcium transport in the intestine (by an epithelial calcium channel, TRPV6) and in the kidney (TRPV5). Normal osteoclastogenesis and bone resorption as well as bone mineralisation is possible in the absence of VDR when VDR KO men or animals receive a high calcium diet. VDR.1α,25-(OH)2</s...