Endocrine Abstracts

HMG CoA reductase, the rate-limiting enzyme in the mevalonate pathway, is 14 steps away from cholesterol synthesis. Statins dramatically reduce the serum concentration of LDL cholesterol by inhibiting this enzyme, but may similarly lower the concentration of many other compounds in the pathway, including ubiquinone (possibly the mechanism of statin-induced rhabdomyolysis though the evidence is far from conclusive). Certain drugs are important co-factors in statin-induced rhabd...