BES2005 Poster Presentations Diabetes and metabolism (35 abstracts)
Cystic fibrosis-related diabetes in adults in Ireland
TJ Cawood 1 , MJ McKenna 1,2 , CG Gallagher 3 , D Smith 1 , WY Chung 1 , J Gibney 1 & D O'Shea 1
1Department of Endocrinology, St. Vincent's University Hospital, Dublin, Ireland; 2Department of Bone Densitometry, St. Vincent's University Hospital, Dublin, Ireland; 3Department of Respiratory Medicine, St. Vincent's University Hospital, Dublin, Ireland.
We aimed to establish the extent of adult cystic fibrosis-related diabetes (CFRD) in Ireland, and examine the differences between patients with CFRD and those with normal glucose handling.
We conducted a retrospective analysis of patients with cystic fibrosis (CF) who attend the national referral centre for adult CF. Data including lung spirometry, sputum microbiology, bone mineral density and genotype were collected. Patients were diagnosed as having CFRD by application of the American Cystic Fibrosis Foundation criteria for diagnosis of CFRD.
Of 259 patients, 150 were classifiable and 81 (54%) were classified as having CFRD. The groups with and without CFRD were not significantly different with regard to age (median 28.4 vs 26.0years), sex (males 56% vs 55%) or BMI (median 20.9 vs 21.3kg/m2). The group with CFRD had poorer lung function (mean % predicted FEV1 49.9 vs 66.4, P<0.001) and poorer bone mineral density, measured by T-scores at the lumbar spine (-1.95 vs -1.44, P<0.05) and femur (-1.19 vs -0.57, P<0.01). The group with CFRD had a greater proportion of Pseudomonas Aeruginosa positive cultures (82.5% vs 64.2%, Chi-squared test, P<0.05). No patients with CFRD carried the R117H mutation whilst 19% of the group without CFRD were heterozygous for this defect (Chi-squared test, P<0.001).
CFRD was highly prevalent in adults. The presence of CFRD was associated with poorer lung function, poorer bone mineral density and an increased prevalence of Pseudomonas Aeruginosa in sputum. The R117H mutation may be protective for CFRD.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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