SFE2004 Poster Presentations Neuroendocrinology and behaviour (12 abstracts)
A rare presentation of a neuroendocrine tumor
SK Attili 1 , A Choudhury 1 , S Roy Chowdhury 2 , GI Varughese 2 & PH Davies 1
1Department of Endocrinology, Sandwell and West Birmingham Hospitals NHS Trust, West Midlands, U.K.; 2Department of Endocrinology, Princess Royal Hospital, Telford, Shropshire, U.K.
Carcinoid tumours are the most common neuroendocrine tumors with an estimated incidence of 7-13/ million population. The clinical symptoms of carcinoid tumours usually relate to presence of the carcinoid syndrome, local symptoms or metastases. Most are asymptomatic with only 10% manifesting the 'carcinoid syndrome'. We report an 86 year-old lady referred for evaluation of multiple subcutaneous, nodules around her neck and upper back, with a suspicion of underlying lymphoproliferative disease. The patient had noticed these painless lumps for 6 weeks. She did not complain of any systemic symptoms, but on direct questioning admitted to a history of intermittent watery diarrhoea and weight loss over the last 6 months. Biopsy of a nodule revealed a poorly differentiated high-grade malignant neoplasm. Immunohistochemistry was positive for chromogranin, CAM 5.2, CK7, AE1 and AE2, but negative for LCA, CD20, S100, UCHL-1, CK20 and melan-A. Thus it was consistent with metastatic neuroendocrine carcinoma. Cutaneous metastasis is very uncommon and usually represents terminal disease. Presentation of carcinoid tumour as cutaneous metastases is extremely rare, with only a few reported cases.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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