Endocrine Abstracts

Contents

• Plenary Lectures
• • Society for Endocrinology Asia and Oceania Medal Lecture
  • • RNA, proteins and hormone action: tales from down under

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    • Society for Endocrinology Asia and Oceania Medal Lecture

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  • Society for Endocrinology European Medal Lecture
  • • Neuroendocrine tumors: From bench to bed - 25 years experience and the future

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    • Society for Endocrinology European Medal Lecture

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  • Society for Endocrinology Medal
  • • Oestrogen and the skeleton

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    • Society for Endocrinology Medal Lecture

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• Basic Science Review Lecture
• • Basic Science Review Lecture
  • • Understanding endocrine development of the human beta cell: guiding stem cell therapy for Type 1 Diabetes

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• Symposia
• • Zonation of the adrenal cortex�molecular signalling
  • • Functional zonation of the adrenal cortex - an overview

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    • Wnt signalling in the adrenal cortex

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    • Adrenomedullin in the adrenal

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    • Paracrine regulation of the adrenal cortex

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  • Stressed mothers: Causes and outcomes
  • • OXYTOCIN AND THE CROSS-GENERATIONAL TRANSMISSION OF MOTHERING AND STRESS RESPONSES

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    • Reproductive hormones: Involvement in maternal stress coping and anxiety

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    • EFFECTS OF PRE-NATAL STRESS ON BEHAVIOUR AND NEUROENDOCRINE ACTIVITY OF PIGS' OFFSPRING

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    • Endocrine-immune bidirectionality in pregnancy: effects of stress and anxiety

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  • Hormones in natural products
  • • Hormones in natural products: an overview

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    • Natural endocrine disrupters in aquatic environments

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    • Gender dysfunction in newborn males

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    • Phytoestrogens - beyond the oestrogen receptor

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  • Consequences of a lack of androgens
  • • ANDROGEN ACTION AND THE MALE ADULT PHENOTYPE FROM YOUTH TO SENESCENCE

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    • CONSEQUENCES OF ANDROGEN RECEPTOR ABNORMALITIES

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    • SARMS(Selective androgen receptor modulators)

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    • Hormonal Male Contraception: An Update

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• Nurses Session
• • Neuroendocrine tumours-an update
  • • Introduction to NET: Definition, classification and diagnosis

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    • The Role of the Nurse Specialist in the Co-ordination of Patient Care

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    • Injection techniquesndashgetting it right

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    • A case of MEN 1 syndrome with secretion of multiple gut hormones

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• Oncology Strand
• • Neuroendocrine Tumours
  • • THE MANAGEMENT OF NEUROENDOCRINE TUMOURS WITH RADIOACTIVE OCTREOTIDE

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    • New Genetic Causes of Pheochromocytoma

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    • Genotype-Phenotype Correlations in von Hippel-Lindau disease

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    • Surgical Aspects of Medullary Thyroid Cancer Treatment

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  • Endocrine aspects of breast cancer
  • • New Pure Antioestrogens

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    • The role of oestrogens in the development of breast cancer

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    • Endocrine treatment of breast cancer

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    • Exercise, obesity and the risk of breast cancer

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• Oral Communications
• • Growth and Development
  • • Rat bone marrow mesenchymal stem cells transdifferentiate into islet-secreting cells in vitro

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    • Insulin transgene overexpression: a tool for characterisation of beta-cell phenotype in transdifferentiation studies

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    • Cell-cell contact enhances insulin secretion from pancreatic beta-cells but not glucagon secretion from alpha-cells

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    • IGF-independent acceleration of myogenesis by IGFBP-5: modulation of cell survival and differentiation signalling pathways

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    • GnRH, anosmin-1 and FGFR1 immunoreactivity in the developing human brain

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    • Overexpression of the imprinted gene Neuronatin represses normal pituitary differentiation

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    • Sexually dimorphic glucocorticoid programming of the hypothalamo-pituitary-prolactin axis

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    • Fetal programming of the endothelial nitric oxide pathway in man

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  • Neuroendocrinology and Reproduction
  • • Triiodothyronine Directly Regulates Feeding

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    • Subcutaneous administration of ghrelin and its effects on food intake in man

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    • Brain-derived neurotrophic factor (BDNF) is a novel steroidogenic factor-1 (SF-1) target gene in the ventromedial hypothalamus (VMH): implications for obesity onset

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    • Macrophage migration inhibitory factor is released from pituitary folliculo-stellate-like cells by endotoxin and dexamethasone and attenuates the steroid-induced inhibition of interleukin 6 release

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    • Reduced expression of anti-Mullerian hormone (AMH) protein in the androgenised sheep ovary

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    • Sickle Cell trait and gender influence type 2 diabetic complications in African patients

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    • PGF2alpha -FP receptor signalling is a potential regulator of endometrial vascular function

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    • Sp1 and CREB promote nectin-2 transcription to regulate adherens junctions assembly in the testis

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  • Young Endocrinologist Session
  • • Regulation of canonical Wnt/beta-catenin signalling pathway plays a central role in the thyroid growth and proliferation in neoplastic thyroid cell lines

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    • Proliferative effects of ghrelin and desoctanoyl ghrelin are independent of the growth hormone secretagogue receptor (GHS-R)

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    • Sp1/Sp3, GnRH and PACAP involvement in C-type natriuretic peptide (CNP/Nppc) expression and action in gonadotrophs

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    • FAILURE OF SUPPRESSION OF ENDOGENOUS GLUCOSE PRODUCTION (EGP) DIMINISHED LIPOLYSIS AND FREE FATTY ACID (FFA) OXIDATION IN A POPULATION AT HIGH RISK OF THE DEVELOPMENT OF TYPE 2 DIABETES

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    • Effect of Variation at the Aldosterone Synthase Locus (CYP11B2) on Adrenal 11-beta hydroxylation: Pilot Data from the MRC BRIGHT Study

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    • Adrenal and circulating agouti related protein (AgRP) is upregulated in Cushing's syndrome suggesting a novel inhibitory paracrine role in the human adrenal gland

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    • A Pilot Study of Prolonged High Dose Rosiglitazone Therapy (12mg/day) in Nelson's Syndrome

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• Poster Presentations
• • Bone
  • • The Effect of BsmI and FokI Genotypes on Bone Density and Bone Turnover Response to Raloxifene Therapy

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    • Serum 25 (OH) D and Dietary Calcium Intake are Associated with Bone Mineral Density Acquisition during Puberty

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    • Depot Medroxyprogesterone Acetate Use is Associated with a Bone Density Deficit in Young Adult Women

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    • Poor Health May Predict Vertebral Fractures but Not Non-vertebral Fractures

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    • The effects of Simvastatin on the human osteoblast-like cell, SaOS-2

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  • Clinical case reports
  • • A young woman presenting with multiple bone swelling, deformities and fractures

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    • Anticoagulation related life threatening electrolyte imbalance in a patient with diabetes mellitus

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    • A sweet case of refractory hypokalaemia

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    • Conservative management of a visual field defect

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    • Hyperinsulinaemic Hypoglycaemia in a Pregnant Patient with Human Immunodeficiency Virus [HIV] Infection

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    • A rare mutation causing Familial Medullary Thyroid Carcinoma

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    • ADDISON'S DISEASE AND CYCLICAL NEUTROPENIA - A DEVASTATING COMBINATION

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    • Running out of sodium

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    • Euglycaemic Diabetic ketoacidosis in pregnancy

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    • Adrenal hypoplasia congenita and hypogonadotropic hypogonadism due to a novel splice site mutation in NR0B1

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    • Inducing weight loss with steroids: a case of neurosarcoidosis

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  • Cytokines and growth factors
  • • SEMINAL PLASMA ACTIVATES SIGNALLING AND GENE EXPRESSION VIA THE EP4 RECEPTOR

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    • Modulation of the circulating insulin-like growth factor system in patients with gastrointestinal inflammation

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    • Age is an important determinant of the growth hormone response to sprint exercise in young men

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    • Low circulating ghrelin levels in gastrectomized patients do not affect the growth hormone response to insulin induced hypoglycemia

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    • MATERNAL COLD EXPOSURE FROM MID TO LATE GESTATION RESULTS IN INCREASED ADIPOSE INSULIN-LIKE GROWTH FACTOR (IGF)-I mRNA EXPRESSION AND HEAVIER BIRTH WEIGHT WITH NO EFFECT ON FAT MASS

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    • Somatostatin Abrogates GH-Induced Hepatocyte IGF-I Transcription by Inhibiting STAT5b Phosphorylation amp Nuclear Translocation

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    • Variability in IGF-I assay performance undermines its contribution to the management of GH axis disorders

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    • Exploiting Phage Technology for Targeting Gene Delivery into the CNS

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  • Diabetes, metabolism and cardiovascular
  • • Interference of signal transduction pathways by Baicalin in insulinoma cell line and its biological significance

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    • Rat pancreatic stellate-like cells differentiate into neuron

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    • EFFECTS OF SYZYGIUM (i) CORDATUM (i) LEAF EXTRACT ON PLASMA GLUCOSE AND HEPATIC GLYCOGEN IN STREPTOZOTOCIN-INDUCED DIABETIC RATS

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    • Altered adrenomedullin (ADM) levels in the central nervous system (CNS) during acute experimental allergic encephalomyelitis (EAE)

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    • Differential effect of maternal nutrient restriction in early to mid and late gestation on uncoupling protein-2 mRNA abundance in adipose tissue of the resulting offspring

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    • EPIDEMIOLOGICAL STUDY ON GLYCEMIA CONTROL IN PATIENTS WITH DM1 AND DM2, Epicon study- baseline visit analysis

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    • METABOLIC EFFECTS OF ANDROGENIC STEROID ABUSE

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    • AUDIT OF MANAGEMENT OF DIABETIC KETOACIDOSIS IN A BUSY DISTRICT GENERAL HOSPITAL

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    • Increased insulin resistance is strongly associated with decreased physical quality of life in elderly subjects from the Hertfordshire Cohort Study, independent of established IHD

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    • Instant 99mTc-ciprofloxacin scintigraphy for the diagnosis of Osteomyelitis in the Diabetic foot

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    • Vasculopathy in Turner Syndrome: Arterial Dilatation and Intimal Thickening without Endothelial Dysfunction

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    • Increasing oestrogen dose reduces intima media thickness in women with Turner Syndrome

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    • CHARACTERISATION OF ADRENOMEDULLIN RECEPTOR (CRLR/RAMP2) EXPRESSION IN HUMAN MICROVASCULAR ENDOTHELIAL CELLS

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    • Comparing Daily Glycaemic Control with Insulin Glargine added to Oral Agents versus Twice-daily Premixed Insulin Alone in Type 2 Diabetes

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    • Evolution of insulin resistance in adolescent and young men

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    • The effects of maternal diet during late pregnancy and body shape at birth on postnatal plasma concentrations of insulin like growth factor 1 (IGF1) and leptin

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    • ELECTRON BEAM CT MEASUREMENT OF CORONARY ARTERY CALCIUM ALLOWS INDIVIDUAL RISK ASSESSMENT OF CHD IN UK DIABETIC PATIENTS

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    • Effect of ghrelin on insulin-stimulated glucose uptake in adipocytes and role of the growth hormone secretagogue receptor type 1a

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  • Endocrine Tumours and Neoplasia
  • • Expression of Bone Morphogenetic Protein receptors in human pituitary adenomas

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    • Diagnosis of a gastrinoma in patients on proton pump inhibitor therapy

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    • Fractionated urinary metanephrines and the diagnosis of phaeochromocytoma

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    • Elevated FP receptor signalling in endometrial adenocarcinoma cells promotes expression of inflammatory and angiogenic genes via the EGFR and ERK1/2 pathways

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    • An audit of long-acting Somatostatin receptor ligand therapy in acromegaly

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    • HISTOPATHOLOGICAL SURPRISE IN A RADIOLOGICALLY PATIENT OF ACROMEGALY: SOMATOROPINOMA WITH NEURONAL CHORISTOMA

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    • Dramatic response with medical treatment of an extensively invasive 'giant' prolactinoma with cabergoline

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    • Prognostic value Carcinoembryonic antigen (CEA)of in patients with the familial medullary thyroid carcinoma (FMTC)

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    • Multiple hepatic embolisations are an effective treatment for metastatic gastrinoma

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  • Growth and development
  • • An inducible gene expression model and expression microarray to determine regulators of human pancreatic beta cell differentiation

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    • Early development and subsequent metabolic parameters in Holstein-Friesian Dairy Cows

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    • Intermittent recombinant growth hormone (Saizen) treatment in short children born small for gestational age: Results of two different treatment regimens on growth parameters after 4 years

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    • The effect of thyroid hormone (T3) and a beta-adrenoceptor agonist on uncoupling protein 3 (UCP3) mRNA expression in porcine adipose tissue (AT)

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    • The influence of environmental temperature and hormonal manipulation on adipose tissue (AT) uncoupling protein (UCP) 3 expression in neonatal pigs

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    • 11beta hydroxysteroid dehydrogenase type 2 (11betaHSD2) is expressed in omental fat of week old lambs

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    • Is the Bone Mineral Density of Adults with GH Deficiency and GH-Insufficiency Truly Reduced?

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    • Urokinase-type plasminogen activator: a novel ligand for anosmin-1, the protein implicated in X-linked Kallmann's syndrome

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  • Neuroendocrinology and behaviour
  • • Stress hyporesponsiveness during pregnancy and parturition: sympathetic and adrenal medulla responses in rodents

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    • Gender and species barrier are linked in BSE transmission to mice

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    • Serum prolactin levels in patients with non-functioning pituitary adenomas and craniopharyngiomas

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    • A rare presentation of a neuroendocrine tumor

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    • Characterization of formylated peptide receptor expression in murine brain, pituitary and adrenal tissue

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    • A Comparative Growth Hormone Study in Acromegaly

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    • PITUITARY FUNCTION IN ADULTS TREATED FOR ACUTE LYMPHOBLASTIC LEUKAEMIA (ALL) DURING CHILDHOOD

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    • Management dilemmas in an Acromegalic twelve years after surgery for subarachnoid haemmorhage

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    • Prolactin secretion in the male annexin 1 knockout mouse: effects of gonadectomy and testosterone replacement

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    • Blood Cerebrospinal Fluid Barrier (BCB) for TSH, Prolactin and Insulin in Pregnancy

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    • Ghrelin increases food intake in obese as well as lean subjects

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    • The C terminal decapeptide from the Kisspeptin stimulates calcium transients in human FNCB4 GnRH expressing human olfactory neuroblasts

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  • Reproduction
  • • Expression of 20alpha hydroxysteroid dehydrogenase in the adrenal cortex during pregnancy

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    • Effect of gonadotrophin and insulin on the balance of sterol regulatory element-binding protein(SREBP) isoforms in human granulosa cells

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    • Evidence for a role of the Type 1 IGF receptor in early follicular development in cultured human ovarian tissue

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    • VARIATION IN PITUITARY EXPRESSION OF BETAGLYCAN, ACTIVIN RECEPTOR SUBTYPES (TYPE I, IIA, IIB) AND GnRH RECEPTOR DURING THE OVULATORY CYCLE OF THE DOMESTIC HEN

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    • Do Androstenedione and DHEAS contribute to the diagnosis of PCOS in GP Patients?

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    • Androgens inhibit atresia and retard early development of ovarian follicles: a model for PCOS?

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    • CHANGES IN OVARIAN MODULATORS OF TYPE 1 11BETA-HYDROXYSTEROID DEHYDROGENASE (11BHSD1) ACTIVITY DURING PORCINE FOLLICULAR GROWTH

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    • Arterial viscoelastic properties and blood pressure in pregnant women with polycystic ovary syndrome

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  • Steroids
  • • Discrepancy between random serum cortisol levels and short synacthen test results in a patient with adrenal insufficiency

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    • PHYTOESTROGENS INHIBIT mRNA EXPRESSION AND ACTIVITY OF AROMATASE IN HUMAN GRANULOSA-LUTEAL (GL) CELLS

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    • Familial Glucocorticoid Deficiency type 2 is associated with mutations in a novel gene encoding a small single transmembrane domain protein

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    • Patient self-monitoring of hydrocortisone replacement

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    • Glucocorticoid metabolism in fatty liver induced by a choline-deficient diet in mice

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    • Functional properties and utility of fusion proteins of type II 3beta-hydroxysteroid dehydrogenase and green fluorescent protein

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    • Variability in Hydrocortisone Pharmacokinetics Following Intravenous and Oral Administration in Patients with Adrenal Insufficiency

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  • Thyroid
  • • Pitfalls of 99mTc-pertechnetate scintigraphy in Postpartum thyrotoxicosis

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    • Thyroid hemiagenesis associated with Graves' disease

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    • The Irrelevance of Anti-thyroid Peroxidase Antibodies

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• Diabetes Strand
• • Lectures
  • • Can we resurrect beta cell function? Insights from GLP-1

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    • New insights into the pathogenesis of diabetic kidney disease

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    • 11beta-hydroxysteroid dehydrogenase type 1: a cause of the metabolic syndrome and therapeutic target

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• Symposium
• • Recent advances in drug delivery and monitoring
  • • Update on Insulin Pump Therapy in the U.K

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    • Continuous Glucose Monitoring

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    • Alternative mechanisms of insulin delivery

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• Expert Sessions
• • Expert sessions
  • • Diabetes, HDL metabolism and cardiovascular disease

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    • Sexual Development

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• Poster Session
• • Diabetes, metabolism and cardiovascular
  • • Anticoagulation related life threatening electrolyte imbalance in a patient with diabetes mellitus

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    • Interference of signal transduction pathways by Baicalin in insulinoma cell line and its biological significance

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    • Rat pancreatic stellate-like cells differentiate into neuron

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    • Rat bone marrow mesenchymal stem cells transdifferentiate into islet-secreting cells in vitro

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    • DIETARY COMPLIANCE OF PATIENTS WITH TYPE 2 DIABETES IN PRIMARY CARE IN GREATER NOTTINGHAM

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    • Assessing the effects of dehydroepiandrosterone replacement on insulin sensitivity and skeletal muscle physiology in hypoadrenal women

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    • METABOLIC EFFECTS OF ANDROGENIC STEROID ABUSE

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    • AUDIT OF MANAGEMENT OF DIABETIC KETOACIDOSIS IN A BUSY DISTRICT GENERAL HOSPITAL

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    • Increased insulin resistance is strongly associated with decreased physical quality of life in elderly subjects from the Hertfordshire Cohort Study, independent of established IHD

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    • All men attending diabetes clinics should have serum testosterone measure as it correlates with HDL and sexual dysfunction

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    • Hyperinsulinaemic Hypoglycaemia in a Pregnant Patient with Human Immunodeficiency Virus [HIV] Infection

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    • Sickle Cell trait and gender influence type 2 diabetic complications in African patients

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    • HISTOPATHOLOGICAL SURPRISE IN A RADIOLOGICALLY PATIENT OF ACROMEGALY: SOMATOROPINOMA WITH NEURONAL CHORISTOMA

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    • Insulin secreted in response to high glucose prevents b-cells from undergoing apoptosis

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    • A Pilot Study of Prolonged High Dose Rosiglitazone Therapy (12mg/day) in Nelson's Syndrome

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    • Vasculopathy in Turner Syndrome: Arterial Dilatation and Intimal Thickening without Endothelial Dysfunction

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    • Increasing oestrogen dose reduces intima media thickness in women with Turner Syndrome

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    • Insulin transgene overexpression: a tool for characterisation of beta-cell phenotype in transdifferentiation studies

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    • Cyclo-oxygenase 2 and prostaglandin E2 protect against apoptosis in MIN6 insulin-secreting cells

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    • The effects of maternal diet during late pregnancy and body shape at birth on postnatal plasma concentrations of insulin like growth factor 1 (IGF1) and leptin

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    • ELECTRON BEAM CT MEASUREMENT OF CORONARY ARTERY CALCIUM ALLOWS INDIVIDUAL RISK ASSESSMENT OF CHD IN UK DIABETIC PATIENTS

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    • Euglycaemic Diabetic ketoacidosis in pregnancy

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    • FAILURE OF SUPPRESSION OF ENDOGENOUS GLUCOSE PRODUCTION (EGP) DIMINISHED LIPOLYSIS AND FREE FATTY ACID (FFA) OXIDATION IN A POPULATION AT HIGH RISK FOR THE DEVELOPMENT OF TYPE 2 DIABETES

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    • Inducing weight loss with steroids: a case of neurosarcoidosis

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• Growth Factors Strand
• • (1)
  • • Growth factors and stem cell research

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    • Imaging tissue repair: Molecular imaging techniques and their role in the characterisation of tissue repair processes

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    • Wound healing studies in mice and flies

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    • Haematopoietic Stem Cells: What Regulates the Regulator?

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    • Biology and Therapeutic Potential of Neural Stem Cells

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    • Directing cells to become muscle

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• Oral Communications (1)
• • (1)
  • • Exploiting Phage Technology for Targeting Gene Delivery into the CNS

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    • siRNA-Mediated Knock Down of NgR, p75NTR and Rho-A Disinhibits Neurotrophin-Induced Dorsal Root Ganglia Neurite Outgrowth on CNS Myelin

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    • VEGF secretion from pituitary folliculo-stellate cells: a role for KATP channels?

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    • IGF-independent acceleration of myogenesis by IGFBP-5: modulation of cell survival and differentiation signalling pathways

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    • Evidence for a role of the Type 1 IGF receptor in early follicular development in cultured human ovarian tissue

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    • THE INSULIN-LIKE GROWTH FACTOR BINDING PROTEIN-5 (IGFBP-5) PROFILE IN PRIMARY CULTURES OF DIFFERENTIATED MOUSE MAMMARY EPITHELIAL CELLS

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    • Modulation of the circulating insulin-like growth factor system in patients with gastrointestinal inflammation

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    • Intermittent recombinant growth hormone (Saizen) treatment in short children born small for gestational age: Results of two different treatment regimens on growth parameters after 4 years

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