Endocrine Abstracts

Contents

• Plenary Lectures
• • Society for Endocrinology Asia and Oceanic Medal Lecture
  • • New insights into growth hormone action

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    • Society for Endocrinology Asia and Oceanic Medal Lecture

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  • Society for Endocrinology European Medal Lecture
  • • GHRELIN AND SYNTHETIC GHS

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    • Society for Endocrinology European Medal Lecture

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  • Society for Endocrinology Medal Lecture
  • • Has the mechanism by which the endocrine placenta scavenges the mother whilst sparing the foetus been unmasked?

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    • Society for Endocrinology Medal Lecture

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• Basic Science Review Session
• • (1)
  • • Y Are Men The Weaker Sex?

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• Symposia
• • Newer concepts of mineralocorticoid action
  • • Extra-adrenal aldosterone synthesis and its role in non-classical target tissues

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    • GENETIC DISORDERS OF MINERALOCORTICOIDS

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    • DIAGNOSIS OF HYPOALDOSTERONISM

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    • Treating Primary Aldosteronism with New Aldosterone Receptor Antagonists

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  • Gaseous signalling
  • • AN OVERVIEW OF GASEOUS SIGNALING BY NITRIC OXIDE

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    • HIF and cancer

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    • NO signalling and endogenous methylarginines

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    • THE HEME OXYGENASE-CARBON MONOXIDE PATHWAY IN THE CONTROL OF NEUROENDOCRINE FUNCTION

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  • Melanocortin receptors
  • • Role of Brainstem Melanocortin System in CCK-mediated Satiety

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    • Brain melanocortin receptors - feeding and energy expenditure

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    • N-terminal POMC ligands and their receptors

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    • Melanocortin receptors in the anterior pituitary

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  • The endocrinologist and bone
  • • OSTEOPOROSIS IN INFLAMMATORY BOWEL DISEASE

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    • 11beta-hydroxysteroid dehydrogenase type 1: a prereceptor regulator of glucocorticoids in bone

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    • Parathyroid hormone in the treatment of osteoporosis: The Dawn of the anabolic era

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    • Statins and Bone

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• Clinical Endocrine Debate
• • This house believes that the investigation of thyroid nodules should be simplified to a syringe and needle
  • • The case for

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    • The case against

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• Nurses Session
• • Steroid replacement
  • • Steroid Replacement Therapy

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    • A Simplfied Protocol for Hydrocortisone Replacement Therapy in Patients with Adrenal Insufficiency

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    • AN AUDIT OF SELF-CARE OF PATIENTS ON HYDROCORTISONE REPLACEMENT THERAPY

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    • Steroid replacement therapy: the challenges of medication management in adrenal insufficiency, with reference to insights from patients' experiences

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• Oral Communications
• • Young Endocrinologist Session
  • • Bicuspid Aortic Valve is associated with increased arterial stiffness in adult women with Turner Syndrome

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    • The nature of the quality of life (QOL) impairment in adult GHD survivors of cancer and their response to GH replacement therapy

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    • Recurrent painful unilateral Gynaecomastia with relapsing Hyperthyroidism

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    • Influence of Annexin 1 gene deletion on dopaminergic cell numbers in the mid-brain

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    • Non-genomic Progesterone Receptors in Human Endometrium

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    • Crosstalk between IGF signalling and cadherin-mediated cell adhesion promotes myogenic differentiation

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  • Reproduction
  • • IGF-I STIMULATES EARLY FOLLICULAR DEVELOPMENT IN CULTURED HUMAN OVARIAN TISSUE

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    • Inverse relationship between aromatase and connective tissue growth factor (CTGF) during rat granulosa cell differentiation

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    • Prokineticins (EG-VEGF and Bv8) and their receptors (PKR1 and PKR2) in the human endometrium

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    • PROSTAGLANDIN EP2 RECEPTOR PROMOTES VEGF EXPRESSION VIA THE EGFR AND ERK1/2 SIGNALLING PATHWAYS

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    • EFFECT OF DIETARY N-6 POLYUNSATURATED FATTY ACIDS (PUFAS) ON PROSTAGLANDINS (PG) PRODUCED BY MATERNAL INTERCOTYLEDONARY ENDOMETRIAL (IC) TISSUES IN LATE PREGNANT EWES

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    • SERUM C-REACTIVE PROTEIN (CRP) IS RELATED TO AGE AND BODY MASS INDEX (BMI) IN PATIENTS WITH POLYCYSTIC OVARY SYNDROME (PCOS) BUT NOT TO INSULIN SENSITIVITY

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    • Resistance to insulin-dependent glucose metabolism in human granulosa-luteal cells from anovulatory women with polycystic ovaries

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    • Expression and signaling characteristics of orexin receptors in the human male reproductive system

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  • Growth and Development
  • • Spontaneous differentiation of mouse embryonic stem cells into an islet phenotype

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    • Overexpression of insulin-like growth factor binding protein-5 (Igfbp5) in mice results in compromised muscle development

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    • BONE MORPHOGENETIC PROTEIN-2 - RECEPTOR EXPRESSION AND FUNCTION IN PITUITARY GONADOTROPHS

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    • Testosterone 17beta-hydroxysteroid dehydrogenase (17beta-HSD) activities of mouse type I and VI 3beta-hydroxysteroid dehydrogenases

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    • DIFFERENTIAL EFFECTS OF MATERNAL NUTRITION ON MOLECULAR INDICES OF FETAL ADIPOSE TISSUE DEVELOPMENT AND FUNCTION

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    • THE EFFECT OF MATERNAL NUTRITION DURING THE FIRST OR SECOND HALF OF GESTATION ON GLUCOSE TOLERANCE OF THE SOW

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    • CHRONIC UMBILICAL CORD COMPRESSION BLUNTS THE FETAL PLASMA ARGININE VASOPRESSIN (AVP) RESPONSE TO SUBSEQUENT ACUTE HYPOXAEMIA

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    • REASSESSMENT OF GROWTH HORMONE STATUS IS REQUIRED AT FINAL HEIGHT IN CHILDREN TREATED WITH GROWTH HORMONE REPLACEMENT FOLLOWING RADIATION THERAPY

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  • Neuroendocrinology
  • • Receptor Shedding: A Novel Mechanism for the Disinhibition of CNS Neuronal Growth

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    • PACAP STIMULATES PHOSPHORYLATION AND LIGAND-BINDING ACTIVITY OF STEROIDOGENIC FACTOR-1 (SF-1) IN alphaT3-1 GONADOTROPHS

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    • Sexual dimorphism in anterior pituitary function in the annexin 1 knockout mouse

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    • Suppression of the hypothalamo-pituitary adrenal axis by long-term intra-arcuate Cocaine- and Amphetamine-regulated transcript (CART) peptide

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    • The MC3-R does not play a role in mediating the effects of gamma-MSH peptides on the adrenal

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    • Safety And Efficacy Of Converting Patients With Acromegaly From Long-Acting Octreotide To Pegvisomant

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    • EFFICACY AND SAFETY OF TITRATED-DOSES LANREOTIDE AUTOGEL IN PATIENTS WITH ACROMEGALY

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    • Circulating Cocaine- and Amphetamine-regulated transcript (CART) peptide in subjects with abnormalities of the hypothalamo-pituitary axis

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• Poster Presentations
• • Clinical case reports
  • • A young woman with allergic rhinitis and proximal myopathy

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    • A CASE OF HYPERTHYROIDISM PRESENTING AS HAEMATOLOGICAL MALIGNANCY

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    • PROFOUND HYPOTHYROIDISM IN A PATIENT WITH LACTOSE INTOLERANCE

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    • Acromegaly with Optic Atrophy in a case of Macroadenoma of pituitary with no pressure effect on Optic Chiasm

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    • An unusual case of phaeochromocytoma

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    • Gestational DI and oligohydramnios

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    • Tuberous Sclerosis and Cushing's syndrome: a rare association

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    • Tall or thin

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    • A RARE CAUSE OF HYPOGLYCAEMIA

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    • Transphenoidal basal encephalocoele presenting with panhypopituitarism

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    • NOW YOU SEE IT, NOW YOU DON'T: A VARIABLE PITUITARY MASS

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    • Uneventful pregnancy in a patient with pituitary apoplexy

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    • Surgical treatment for insulinoma and disappearance of type 2 diabetes mellitus

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    • Relapsing lymphocytic hypophysitis with progressive hypopituitarism and permanent neurological deficit

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    • A Case of ACTH Secreting Benign Mediastinal Carcinoid with Hypocalcaemia

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    • What is the Clinical Relevance of Macroprolactinaemia? A Clinical Case Report

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    • PERSISTENT VOMITING: AN UNCOMMON PRESENTING SYMPTOM OF THYROTOXICOSIS IN A WOMAN WITH TYPE 1 DIABETES MELLITUS

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    • RECOGNIZING PARATHYROID CARCINOMA

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  • Cytokines
  • • EFFECT OF CATHEPSIN D AND PROSTATE SPECIFIC ANTIGEN ON LATENT TRANSFORMING GROWTH FACTOR-BETA IN BREAST CANCER CELL LINES

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    • EFFECT OF MATERNAL NUTRIENT RESTRICTION DURING LATE-GESTATION ON THE HEPATIC INSULIN-LIKE GROWTH FACTOR (IGF) SYSTEM IN NEONATAL SHEEP

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    • EFFECT OF CHRONIC PROLACTIN ADMINISTRATION ON THE SOMATOTROPHIC AXIS IN ONE-WEEK-OLD LAMBS

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    • INVESTIGATION OF GROWTH HORMONE SECRETION AND SENSITIVITY IN RHEUMATOID ARTHRITIS

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    • GH and nitric oxide production by pig pituitary cells in different culture conditions

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    • Pro-adrenomedullin N terminal 20 peptide (PAMP) causes proliferation of human endothelial and adrenocortical cells

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  • Diabetes, metabolism and cardiovascular
  • • Relationship between insulin resistance and exercise test parameters in asymptomatic type II diabetics without any documented evidence of coronary artery disease

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    • Pancreatic islet protective effect of vanadium in streptozotocin-induced diabetic rats, histological, immunohistochemical and ultrastructural study

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    • Testosterone-Induced Vasodilatation Of Isolated Human Mesenteric Resistance Arteries Is Independent Of The Vascular Endothelium

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    • The relationship between serum levels of testosterone and inflammatory cytokines in men wih coronary artery disease

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    • HYPERTENSION AND PLASMA RENIN ACTIVITY IN WOMEN WITH TURNER SYNDROME

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    • DOES INSULIN FORMULATION MATTER IN ANTENATAL DIABETES CARE?

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    • THE EFECTS OF ACUTE HYPERINSULINEMIA AND INSULIN SENISTIVITY ON PLASMA HOMOCYSTEINE IN NON-OBESE WOMEN WITH POLYCYSTIC OVARY SYNDROME

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  • Endocrine tumours and neoplasia
  • • Extracts from the Marine Sponges Anthosigmella varians (AV) and Spongia barbara (SB) Lower Cyclin B1 Levels, Cause a G2/M Cell Cycle Block and Trigger Apoptosis in SW-13 Human Adrenal Carcinoma Cultures

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    • CYCLOSPORIN A ENHANCES CERAMIDE SIGNALLING IN HUMAN BREAST CANCER CELLS IN RESPONSE TO N-(4-HYDROXYPHENYL) RETINAMIDE

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    • TITLE: Acquired prolactin deficiency (APD) reflects residual pituitary function after treatment for Cushing's disease

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    • PHAEOCHROMOCYTOMA AND MULTIFOCAL GASTROINTESTINAL STROMAL TUMOURS:CARNEY TRIAD VARIANT OR A NEW SYNDROME?

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    • AN AUDIT OF SESTAMIBI SCANNING IN THE INVESTIGATION OF PRIMARY HYPERPARATHYROIDISM

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    • THE SENSITIVITY OF (super)123I-MIBG IN THE DETECTION OF HISTOLOGICALLY CONFIRMED CATECHOLAMINE-PRODUCING TUMOURS

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    • Macroprolactinomas in men: long-term efficacy of bromocriptine treatment

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    • Normalisation of serum IGF-I by pegvisomant is not associated with a reduction in median nerve size in patients with active acromegaly

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    • Ghrelin and a Novel Ghrelin Isoform Have Potential Autocrine/Paracrine Roles in Hormone-Dependent Cancer

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    • Use of Continous glucose monitoring system in the medical management of insulinomas

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    • The effect of pegvisomant therapy on plasma levels of matrix metalloproteinases 2, 9 and vascular endothelial growth factor in patients with acromegaly

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    • Intraoperative parathyroid hormone (PTH) determinations

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    • SUBCLINICAL GROWTH HORMONE EXCESS, SIGNIFICANT OR IRRELEVANT?

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  • Growth and development
  • • EFFECTS OF MATERNAL COLD EXPOSURE DURING LATE GESTATION ON GHRELIN mRNA ABUNDANCE IN THE OVINE LIVER

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    • CHRONIC UMBILICAL CORD COMPRESSION BLUNTS THE ARGININE VASOPRESSIN RESPONSE TO SUBSEQUENT ACUTE HYPOXAEMIA IN SHEEP DURING LATE GESTATION

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    • Effect of protein supplementation to the mother at specific stages of gestation on fetal adipose tissue

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    • The influence of birth weight on adipose tissue (AT) uncoupling protein 3 (UCP3) expression and thyroid regulation in neonatal pigs

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    • Lanreotide Autogel in acromegaly: a pharmacokinetic and pharmacodynamic analysis

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    • QLS-H, A MEASURE OF QUALITY OF LIFE IN ADULT UK GHD PATIENTS

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  • Neuroendocrinology and behaviour
  • • QLS-H, A MEASURE OF QUALITY OF LIFE IN ADULT UK GHD PATIENTS

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    • The oxytocin response to increased plasma sodium following ovariectomy and oestrogen replacement

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  • Bone
  • • sRANK-L AND OPG ARE INCREASED IN SOME OSTEOPOROTIC PATIENTS

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    • VITAMIN D INSUFFICIENCY AND PLASMA LEVELS OF sRANK-L and OPG IN OSTEOPOROTIC WOMEN

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    • sRANK-L AND OPG CORRELATE WITH BONE MINERAL DENSITY IN OSTEOPOROSIS

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  • Reproduction
  • • Ovarian follicle culture: an old technique revisited

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    • Audit of the effects of Sibutramine and Metformin in the management of Polycystic Ovarian Syndrome - clinical experience from an endocrine clinic

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    • Vascular endothelial growth factor (VEGF), its receptors (KDR and Flt-1) and eNOS are up-regulated in the rat uterine cervix during pregnancy

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    • Aromatase is abundantly expressed in neonatal rat penis but down-regulated in adulthood

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    • Prostaglandin production and timing of parturition in sheep fed a diet high in n-6 polyunsaturated fatty acids

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    • Hyperemesis in pregnancy not the usual suspects

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    • THE INFLUENCE OF POLYCYSTIC OVARY SYNDROME ON OVARIAN GENE EXPRESSION

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  • Steroids
  • • The short synacthen test and the overnight metyrapone test in the investigation of adrenal suppression in patients on prednisolone therapy

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    • Opposite effects of dexamethasone and oestardiol on annexin 1 expression

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    • Hydrocortisone Induced Inhibition of Nuclease Activities in Rat Liver Nuclei

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    • DESIGN OF OESTROGEN RESPONSIVE REPORTER CONSTRUCTS FOR USE IN CELL CULTURE: USE OF CMV PROMOTER

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    • Estradiol Action on Phospholipid Composition of Rat Liver Chromatin

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    • REDUCED EXPRESSION OF 11BETA-HYDROXYSTEROID-DEHYDROGENASE TYPE 2 IN KIDNEY BIOPSIES OF PATIENTS WITH RENAL FAILURE

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    • Effects of food deprivation on the expression and signalling of orexin and orexin receptors in the rat hypothalamus and adrenal gland

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    • OESTROGEN RECEPTOR ALPHA (ERalpha) BUT NOT OESTROGEN RECEPTOR BETA (ERbeta) EXPRESSION IS DOWNREGULATED BY DEXAMETHASONE IN HUMAN SCALP HAIR DERMAL PAPILLA CELLS

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    • Normal Synacthen Test response and Evolution of Schmidt's Syndrome in brittle Type 1 Diabetes

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  • Thyroid
  • • An epidemiological clinical study on Ukrainian patients with severe postoperative hypoparathyroidism using a new questionnaire instrument

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    • Management of thyroid nodule Audit

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    • AN AUDIT OF THE MANAGEMENT OF DIFFERENTIATED THYROID CANCER IN A SPECIALIST CLINIC IN A LARGE DISTRICT HOSPITAL

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    • An Audit of Initial Management of Thyroid Nodules in secondary care

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    • Urticaria The Presenting Symptom Of Thyrotoxicosis

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• Lectures
• • Hypertension and diabetes
  • • Mechanism of hypertension-mediated end-organ damage in diabetes

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    • Mechanisms contributing to hypertension in type 2 diabetes

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    • Epidemiology of hypertension and diabetes

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• Symposium
• • Hypertension
  • • Genetics: Polymorphisms linking hypertension and type 2 diabetes

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    • Vascular cell dysfunction in hypertension and diabetes

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    • Diabetes amp Hypertension: Causes, Investigations and Management

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• Expert Session
• • Diabetes
  • • Hypoglycaemia

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    • Diabetes and Pregnancy

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• Debate
• • Management of the hypertensive diabetic patient
  • • Diabetic Hypertension: Best left to the Diabetologist

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    • Diabetic Hypertension: Best Left to the Cardiologist

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• Poster Presentations (1)
• • Diabetes, metabolism and cardiovascular
  • • Silent myocardial ischemia in patients with type II diabetes mellitus without the clinical manifestations of ischemic heart disease in Turkish population

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    • Diurnal variation in insulin sensitivity

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    • Pancreatic islet protective effect of vanadium in streptozotocin-induced diabetic rats, histological, immunohistochemical and ultrastructural study

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    • AMBULATORY BLOOD GLUCOSE MEASUREMENT IN A NON-PATIENT GROUP OF WOMEN REPORTING SYMPTOMS OF REACTIVE HYPOGLYCAEMIA

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    • AN AUDIT OF THE MANAGEMENT OF DIFFERENTIATED THYROID CANCER IN A SPECIALIST CLINIC IN A LARGE DISTRICT HOSPITAL

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    • An unusual case of phaeochromocytoma

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    • MODULATION OF NICOTINE MEDIATED RESPONSES IN HUMAN GINGIVAL FIBROBLASTS BY PLATELET DERIVED GROWTH FACTOR (PDGF) AND THE ALKALINE PHOSPHATASE INHIBITOR LEVAMISOLE

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    • TRANSFORMING GROWTH FACTOR BETA (TGF) and INSULIN LIKE GROWTH FACTOR (IGF) MEDIATED RESPONSES, TO SERIAL CONCENTRATIONS OF NICOTINE, USING ANDROGEN BIOMARKERS IN HUMAN GINGIVAL FIBROBLASTS

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    • Treatment of metabolic syndrome with topiramate. An open study

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    • Confirmation of altered hypoglycaemia awareness by structured questionnaire and continuous ambulatory glucose profiles in those with Type 1 diabetes mellitus complicated by severe hypoglycaemia

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    • A Prospective Audit of Triple Therapy in Type 2 Patients

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    • NOW YOU SEE IT, NOW YOU DON'T: A VARIABLE PITUITARY MASS

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    • ASYMPTOMATIC TYPE 1 DIABETES MELLITUS

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    • Onset of insulin-resistant stage in a Type II diabetic rat model is associated with diminished levels of vascular endothelial growth factor (VEGF) and its receptors in the penis: implications in the pathogenesis of erectile dysfunction in diabetes

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    • Estradiol Action on Phospholipid Composition of Rat Liver Chromatin

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    • An Audit of Initial Management of Thyroid Nodules in secondary care

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    • THE EFFECT OF MATERNAL NUTRITION DURING THE FIRST OR SECOND HALF OF GESTATION ON GLUCOSE TOLERANCE OF THE SOW

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    • PHAEOCHROMOCYTOMA AND MULTIFOCAL GASTROINTESTINAL STROMAL TUMOURS:CARNEY TRIAD VARIANT OR A NEW SYNDROME?

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    • Effect Of The Mode Of Conception On Incidences Of Apoptotic And Proliferative Cells In Full Term Human Placentas

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    • PITUITARY METASTASIS FROM AN UNKNOWN PRIMARY

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    • An Audit On Adherence To Renal Guidelines in Prevention and Early Management of Renal disease in Type 2 Diabetes

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    • A Case of ACTH Secreting Benign Mediastinal Carcinoid with Hypocalcaemia

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    • Use of Continous glucose monitoring system in the medical management of insulinomas

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    • Evidence for a cholinergic defect in the brain of the obese-diabetic (ob/ob) mouse

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    • Effect of beta-endorphin on glucose uptake and muscle fatigue in resting and contracting muscles of normal and obese-diabetic (ob/ob) mice

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    • SERUM C-REACTIVE PROTEIN (CRP) IS RELATED TO AGE AND BODY MASS INDEX (BMI) IN PATIENTS WITH POLYCYSTIC OVARY SYNDROME (PCOS) BUT NOT TO INSULIN SENSITIVITY

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    • DOES INSULIN FORMULATION MATTER IN ANTENATAL DIABETES CARE?

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    • Prevalence and Management of Cardiovascular disease in a Diabetic-Renal cohort

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    • Spontaneous differentiation of mouse embryonic stem cells into an islet phenotype

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    • What is the Clinical Relevance of Macroprolactinaemia? A Clinical Case Report

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    • Bicuspid Aortic Valve is associated with increased arterial stiffness in adult women with Turner Syndrome

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    • Normal Synacthen Test response and Evolution of Schmidt's Syndrome in brittle Type 1 Diabetes

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    • QLS-H, A MEASURE OF QUALITY OF LIFE IN ADULT UK GHD PATIENTS

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