BES2003 Poster Presentations Bone (13 abstracts)
Iranian national osteoporosis prevention plan-1 (inop-1): preliminary report: Relationship between vitamin d deficiency and markers of bone metabolism in urban 20-69 year-olds in Tehran, Iran
M Pajouhi , B Larijani , S Hashemipour , H Adibi , A Shafaee , M Sedaghat & A Khalilifard
Endocrinology and Metabolism Research Centre,Tehran University of Medical Sciences, Tehran, Iran.
The relationship between vitamin D deficiency and markers of bone metabolism is well established. We assessed, as part of the first Iranian National Osteoporosis Plan (INOP-1), the association between vitamin D deficiency and markers of bone metabolism. 1200 adult men and women, aged 20-69 years, were selected at random for this study in March 2001. Each participant provided a fasting blood sample for measurement of 25(OH)D, PTH, Ca, P, alkaline phosphatase, albumin and total protein, after which he or she underwent bone densitometry by dual-energy X-ray absorptiometry. Severe vitamin D deficiency (VDD) (25(OH)D <or=12.5nmol/l) was seen in 9.3% of the sample, and of moderate VDD (12.5 < 25(OH)D <or=25nmol/l) in 56.4%. There was a significant difference in PTH levels between individuals with 25(OH)D <35nmol/l and those >35nmol/l. The range for mild VDD was thus determined to be 25<25(OH)D<or=35nmol/l, and was subsequently detected in 13.9% of the sample. Serum calcium concentration was significantly lower in individuals with moderate/severe VDD than in those with mild VDD or normal vitamin D status. Mean serum PTH was significantly higher than normal with all degrees of VDD. One or more abnormal serum markers were present in 24.2%, 13.8%, and 6% of those with severe, moderate and mild VDD, respectively. In conclusion, the prevalence of vitamin D deficiency in Iran is very high, and the measurement of serum calcium and/or PTH is not a sensitive marker of vitamin D deficiency.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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