SFE2002 Symposia Transcriptional control of endocrine development and function (4 abstracts)
Cell Fate and Hormonal Regulation of the Pituitary Gonadotrope
PL Mellon , SBR Jacobs , JS Bailey , TJ Spady , D Coss , VV Vasilyev & F Pernasetti
Reproductive Medicine and Neurosciences, University of California, San Diego, USA.
Reproduction is controlled by hypothalamic GnRH acting on the pituitary gonadotrope to regulate LH and FSH. Activin, follistatin, and gonadal steroids modulate the gonadotrope as well. We have created immortalized pituitary gonadotropes and a series of their progenitor cells that represent sequential stages of differentiation. These have allowed the identification of transcription factors responsible for specific developmental transitions such as the initiation of LH and FSH gene expression in development. GnRH activation of the LH and FSH beta-subunit genes is restricted to the most differentiated of the gonadotrope cell lines. This cell line expresses GnRH receptor, activin, follistatin, inhibin, ER, AR, and GR, as well as FSH and LH. FSH beta induction by GnRH or androgen is dependent on the activin autocrine loop. Thus, the most differentiated gonadotrope cell line has allowed dissection of the molecular mechanisms of androgen, activin, and GnRH action and the interdependence of these key modulators of reproductive function.
Article tools
My recent searches
My recently viewed abstracts
Authors
Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
© Bioscientifica 2024 |
Privacy policy |
Cookie settings
BiosciAbstracts
Bioscientifica Abstracts is the gateway to a series of products that provide a permanent, citable record of abstracts for biomedical and life science conferences.
Find out more