Searchable abstracts of presentations at key conferences in endocrinology
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193rd Meeting of the Society for Endocrinology and Society for Endocrinology joint Endocrinology and Diabetes Day

ea0004s4 | (1) | SFE2002

Steroidogenic Factor-1: A Pivotal Regulator of Gonadotroph Gene Expression

R#C##Fowkes|#

The glycoprotein hormone common alpha-subunit (alphaGSU) is an early endocrine marker of pituitary development and is expressed concurrently with the orphan nuclear receptor, steroidogenic factor-1 (SF-1). Our studies have examined the potential role of SF-1 in alphaGSU gene expression using two gonadotroph-derived cell lines as models of the developing pituitary.We investigated the role of SF-1 and its binding site, the gonadotroph-specific element (GSE...