Endocrine Abstracts

Aims:It is currently well known the pathogenic relationship between abdominal obesity(AO),impaired glucose tolerance(IGT)and insulin resistence(IR).We have proposed the studying of presence of a correlation between the obesity degree,established with the help of the body mass index(BMI)and of its type(indicated by the waist-hip ratio-(WHR)with a IGT frequency or of the non-insulin-dependent diabetes mellitus(NIDDM)and of the hyperinsulinemia(HI)in a bihor county population group.

Methods:The appreciation of the NIDDM prevalence and of the IGT by establishing the glycemia and the OGTT(oral glucose tolerance test)respectively with 75g pulvis glucose at 250 subjects and the interpreting of the results according WHO criteria,taking into account the obesity degree(BMI)and its type(WHR).

Results:The prevalence of the increased insulinemia,of the IGT and of the NIDDM has been significantly greater with the subject having an android conformation(WHR>0.85)in comparsion with those having a ginoid conformation(WHR<0.85)8.01%in comparison with 2.71%,p<0.05 for NIDDM and 6.13% respectively in comparison with 1.08%,p<0.05 for IGT.Increased insulinemia have been noticed with 91% of AO cases and 63%of IGT or NIDDM cases AND 96% of AO cases with IGT or NIDDM.Patients with NIDDM we have noticed correlation between BMI and glycemia at 1hour(r=0.25;0.1<p<0.2), at 2hour(r=0.42;0.01<p<0.02).The subjects with IGT we have noticed significant associations only between BMI and fasting glycemia(r=0.53;0.001<p<0.01)at 2hours(r=0.38;0.02<p<0.05).

Conclusions:1.We have noticed a significant statistical correlation between AO,IGT,NIDDM and HI.

2.The incidence of HI increases with association of several pathologic conditions:AO+IGT,AO+NIDDM.

3.The presence of HI from the beginning with agreat incidence in all cases filling the above mentioned conditions suggests causal or the determining role of this pathologic state.