BES2002 Poster Presentations Diabetes & Metabolism (35 abstracts)
Effects of growth hormone replacement (GHR) on VLDL and LDL APOB100 kinetics in growth hormone deficient (GHD) subjects
TM Kearney 1 , C Navas de Gallegos 1 , A Miras 1 , K Parker 2 , V Anayaouku 1 , R Gray 1 , S Venkatesan 1 & DG Johnston 1
1Department of Metabolic Medicine, St. Mary's Hospital, ICSTM, London, UK; 2Department of Physiological Flow Studies, ICSTM, London, UK.
Background. Hypopituitarism is associated with increased VLDL and LDL apoB concentrations, which may be attributable to GHD. Studies examining the effects of GHR on VLDL apoB kinetics have been conflicting, possibly due to differences in the duration of GHR. As yet, the effects of GHR on LDL apoB kinetics are unknown. Aim. To examine the effect of GHR on VLDL and LDL apoB kinetics, and to explore the hypothesis that these effects are dependent on the duration of therapy. Methods. VLDL and LDL apoB kinetics were examined in 16 growth hormone deficient (GHD) subjects after eight weeks (double blind, placebo controlled) and again after forty weeks (open phase) of GHR, using a novel adaptation of a classical stable isotope (13C leucine) technique. Results. Eight weeks of GHR were associated with a reduction in the VLDL apoB absolute secretion rate (ASR, p=0.03), with non-significant reductions in fractional secretion rate (FSR, p=0.09) and pool size (p=0.09). Forty weeks of GHR induced a non-significant reduction in the VLDL apoB ASR (p=0.07), with a return of FSR and pool size to baseline values. GH therapy for 40 weeks induced an increase in LDL apoB FSR (p=0.02) and an increase in LDL apoB ASR (p=0.04), with a modest decrease in pool size. Conclusion. GHR reduced the over-secretion of VLDL associated with hypopituitarism and increased LDL turnover. This may represent important anti-atherogenic effects.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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