Endocrine Abstracts

Much less information is available on the thyroid hormones at different age groups, laying, non-laying and methimazole (MMI) treated japanese quails. All birds were kept under 14:10 hour light schedule and were provided feed and water adlibitum. Fifteen japanese quailsin each age groups, laying, non-laying and MMI treated were decapitated for collection of plasma. Thyroid hormones (T3 and T4) were estimated using ELISA commercial kits. The results showed that plasma thyroid ho...

Eight healthy pregnant goats, aged 2-4 years, were selected for this study. Blood samples were obtained in tubes containing EDTA at different stages of pregnancy, at parturition and on days 1, 7 and 14 postpartum. Blood from foeti was also collected on days 1 and 7 after their birth. Plasma was separated, frozen at -20 celsius till analysed for thyroid hormones (T3 and T4) using ELISA comercial kits. Thyroxine (T4) concentration was higher during prepartum, decreased significa...

In laboratories employing 'front-line' sensitive TSH measurement, it is generally accepted that fully suppressed TSH levels (3rd generation assays) alongside normal free thyroid hormone levels indicate subclinical hyperthyroidism. However, low but not suppressed levels are often labelled as non-thyroidal illness.We investigated 25 successive ambulant individuals, identified over an 18 month period as having low but not fully suppressed TSH levels (3rd ge...

Liver fatty acid-binding protein (LFABP) is a 14 kDa cytoplasmatic protein found in hepatocytes and enterocytes of the small intestine. It binds long chain fatty acids (LCFA) and other hydrophobic ligands and is thought to play an important role in intracellular LCFA transport.We investigated the regulation of LFABP gene expression by thyroid hormone (T3) and peroxisome proliferator-activated receptor alpha (PPARalpha) ligand clofibric acid.<p class=...

Background and Aims: Recent studies have suggested that maternal thyroid dysfunction, particularly in early pregnancy, may have a detrimental effect on the neuropsychological development of offspring. In the light of these studies a local guideline was drawn which recommended screening thyroid function at booking in all pregnant women with a personal or family history of thyroid disease. The aims of this study were to assess adherence to this guideline, and to test its efficac...

Maternal hypothyroidism disrupts fetal brain development in the rat; affected parameters include several neuron-specific cytoskeletal proteins and neurotransmitter metabolic enzymes. The aim of this study was to determine whether maternal hyperthyroidism also impacts upon fetal neuronal development.Partially thyroidectomised rat dams were subcutaneously implanted with osmotic pumps to infuse either 1.5 micrograms thyroxine/100 g body weight/day (HYPER) o...