Endocrine Abstracts

The identification of leptin as a gene product produced in fat revitalised interest in the means by which the brain receives signals to regulate appetite, energy expenditure and the neuroendocrine system. We have studied the effects of alterations in bodyweight on the expression of appetite regulating peptides in the brain and have also determined effects of leptin on a range of parameters in the hypothalamus and pituitary gland of the ovariectomised female sheep. Intracerebro...

Iain Clarke, Prince Henry's Institute of Medical Research, Clayton, Australia AbstractDr Clarke is a leading researcher in the field of neuroendocrinology. In the early 1980s he and Mr James Cummins (a neurosurgeon at St Vincent's Hospital) developed methodology to enable the collection of blood from the hypophseal portal system. This permitted the first ever measurements of real-life secretions of brain hormones unde...