Endocrine Abstracts

Purpose: We found the hypomethylation status of CYP11B2 gene in the aldosterone-producing adenomas compared with normal adrenal glands or non-functioning adrenal adenomas and reported that the methylation of promoter region of this gene influenced the mRNA expression in the adrenal cells. Angiotensin II or potassium regulates CYP11B2 gene expression in the adrenal cells. In order to clarify the acute effect of potassium on the methylation status of CYP11B2 gene, Human adrenal ...

The activation of local renin-angiotensin-aldosterone system (RAAS) plays a pivotal role in the overall pathophysiology of the cardiovascular diseases. We have reported increased mRNA levels of angiotensinogen, angiotensin converting enzyme (ACE) and CYP11B2 (aldosterone synthase gene) in the heart of salt-sensitive hypertensive rats complicated with cardiac hypertrophy. However, the mechanism of control of gene expression of each component of RAAS gene in the heart is unknown...