Endocrine Abstracts

Objective: Decline in the number of D2 receptor (D2R) is considered as the reason of resistance to dopamine agonists (DA). PP4R2 gene was observed up-regulated in prolactinoma patients according to our previous genechip study. In this study, we demonstrated that PP4C was crucial for D2R expression and PRL secretion in rat pituitary MMQ cells.Methods: In this study, we used rat pituitary MMQ cells which could secrete abundant prolactin and express functio...