Endocrine Abstracts

Introduction: Dysgonosomies are abnormalities of the number of gonosomes X and Y. They have fewer Phenotypic repercussions than the aneuploidies involving autosomes, and are mostly viable. The 47 XYY are generally boys with normal phenotype. The prevalence is around 1 per 1000 birth boy but undoubtedly under diagnosed given the often normal phenotype associated with this chromosomal formula, in addition to the lack of large-scale studies. There is no gonadal dysgenesis and oft...

Introduction: Dysgonosomies are abnormalities of the number of gonosomes X and Y. They have fewer Phenotypic repercussions than the aneuploidies involving autosomes, and are mostly viable. The 47 XYY are generally boys with normal phenotype. The prevalence is around 1 per 1000 birth boy but undoubtedly under diagnosed given the often normal phenotype associated with this chromosomal formula, in addition to the lack of large-scale studies. There is no gonadal dysgenesis and oft...

Pregnancies in women with acromegaly are rare. Data from the literature report the absence of fetal malformation, a rarely symptomatic increase in adenomatous volume, a possible risk of gestational diabetes and gravidic hypertension in women not controlled before pregnancy. We report the case of a 32-year-old woman, nulliparous, who consults for spaniomenorrhea associated with chronic headaches, in whom the diagnosis of acromegaly was suspected in the face of a very discreet a...

Introduction: Proximal myopathy presents as symmetrical weakness of proximal upper and/or lower limbs. There is a broad range of underlying causes including drugs, alcohol, endocrine and metabolic myopathies such as primary hyperparathyroidism.Observation: We describe a 48-year-old male, hospitalised in neurology departement for exploration of severe proximal myopathy. Cliniquely, he presented progressive debilitating muscle weakness, severe muscle wasti...

Introduction: Prolactin-secreting tumors or prolactinomas comprise the most common pituitary tumor type, acconting of 47-66% of all pituitary tumors. These tumors can be treated with dopaminergic drugs (DA) however 10-15% of prolactinomas are DA resistant.Case 1: A 39 years old man followed for a geant agressif prolactinoma discovered following a progressive decline in visual acuity and associated with visual impairment (diplopia), the MRI of the sellar ...

Introduction: Pituitary adenomas, more recently referred to as pituitary neuroendocrine tumors (PitNets) from other organs, are common neoplasms comprising 10 to 20% on intracranial tumors. Null cell adenoma is a diagnosis of exclusion that requires immunonegativity for all adenohypophyseal hormones and a lack of cell type-specific transcription factors. It represents 0,6% of all pituitary tumors. Case: A 55 years old women with a history of treated thyr...

Introduction: Pheochromocytomas and paragangliomas (PPGLs) are chromaffin cell tumors that arise from neuroectodermal cells. These tumors are characterized by a very heterogeneous natural history and an unpredictable ability to metastasize. The rate of metastatic disease ranges from lessthan 1% to 79%, depending on tumor site and size, age at diagnosis and genotype.30% are considered to be hereditary. Primary hyperparathyroidism can be associated with PPLGs. We report a case o...

Introduction: The Munchausen syndrome, also known as factitious disorder, involves a compulsion to simulate illness or trauma. Individuals may go as far as taking medication or inflicting harm on their bodies to evoke compassion. The aim of this report is to illustrate the example of factitious hypoglycemia, one of the most common forms of factitious disorders in the endocrine-metabolic field, accounting for 4-11% of all non-diabetic hypoglycemias.Observ...

Introduction: Paragangliomas are chromaffin cell tumors that arise from neuroectodermal cells. Multiple paragangliomas in the same patient are highly uncommon. These tumors have a variable clinical picture, and a very heterogeneous evolution. The pulmonary localization is one of the most frequent, representing 20 to 30% of all neuroendocrine tumors. The silent or aggressive character causes problems in diagnosis, management and prognosis.Case report: We ...

Introduction: Tumors of the pineal region are rare, constitute 0.5% to 1% of intracranial tumors in adults in Europe and the United States. Anatomical location deeply buried under the cerebral hemispheres behind the third ventricle and the brainstem, and the variety of different histological types explain management difficulties. Cysts of the pineal gland, often calcified, may go unnoticed and be discovered during autopsy especially in the elderly, but some cysts are symptomat...