Searchable abstracts of presentations at key conferences in endocrinology

ea0006p17 | Cytokines | SFE2003

EFFECT OF CATHEPSIN D AND PROSTATE SPECIFIC ANTIGEN ON LATENT TRANSFORMING GROWTH FACTOR-BETA IN BREAST CANCER CELL LINES

Lai L , Wong S

Transforming growth factor-beta (TGF-beta)is present, predominantly in latent forms, in normal and malignant breast tissue. The mechanisms by which TGF-beta is activated physiologically remain largely an enigma. The aim of this study was to assess whether the proteases, cathepsin D and PSA could activate latent TGF-beta 1 and 2 in the MCF-7 hormone responsive and MDA-MB-231 hormone unresponsive human breast cancer cell lines. For the experiments, 1 x 106cells were s...

ea0085p27 | Gonadal, DSD and Reproduction | BSPED2022

Delayed puberty is very common in boys with duchenne muscular dystrophy on daily glucocorticoid-implications for management and age to initiate testosterone

Denker M , Dunne J , Horrocks I , Joseph S , Wong SC

Objectives: Delayed puberty is thought to be common in boys with Duchenne muscular dystrophy [DMD]. To date, studies addressing its frequency are not available. This study aims to report the frequency of delayed puberty in DMD from clinical examination.Methods: All boys with DMD aged at least 14 years in January 2022 known to the Glasgow paediatric neuromuscular service (2015-2022) were included. Thirty-seven boys were identified. All 37 boys had at leas...

ea0039oc5.9 | Oral Communications 5 | BSPED2015

Assessing aortic dilatation using aortic sized index is inappropriate in children and adolescents with Turner syndrome

Wong S C , Ehtisham S , Cheung M , Zacharin M

Background: Aortic sized index (ASI) defined as aortic dimensions/body surface area (BSA), has been proposed as a method of identifying aortic dilatation in Turner syndrome. A recent paper reported centile charts of aortic dimensions across for BSA using echocardiogram in 451 children and adults with TS allowing for calculation of Z scores.1Methods: We report Z scores for aortic root adjusted for BSA from clinical echocardiog...

ea0039ep98 | Other | BSPED2015

Cardiovascular assessment in Turner syndrome: current practice in the UK

Mason A , Smyth A , Ahmed S F , Wong S C

Background: In 2007, the Turner syndrome (TS) consensus study group developed an international guideline for clinical care of girls and women with TS. Given emerging concerns of long term cardiovascular complications, the consensus recommends that cardiac MRI should be performed when girls are old enough to tolerate the procedure or at the time of transition and to be repeated at least every 5–10 years.Method: We conducted a survey ...

ea0039ep112 | Pituitary and growth | BSPED2015

Skeletal disproportion in Turner syndrome

McVey L , Fletcher A , Donaldson M D , Wong S C , Mason A

Aims: The aim of this study is to evaluate sitting height (SH) and leg length (LL) in girls with Turner syndrome.Methods: Retrospective study of SH and LL SDS, using SH–LL SDS (~0 in a proportionate child) as a measure of disproportion in 76 girls with Turner syndrome. Eligible girls were aged at least 4 years, had not started recombinant GH, and had no other chronic disease. 40 girls with measurements prior to pubertal induction and at adult height...

ea0038p477 | Thyroid | SFEBES2015

Investigating pyrexia whilst awaiting thyroidectomy for Thy 3, Hurthle cell neoplasia

Loumpardia P , Dacruz T , Zeitoun H , Wong S P Y

Thyroid abscess is a rare condition because of the thyroid gland anatomical and biochemical nature. We report a rare case of a rapidly developed thyroid abscess in the background of follicular thyroid nodule.A 77 years old lady admitted for elective right thyroidectomy. She had a history of goiter with normal TFTs. FNA cytology revealed Thy3, Hurthle cell neoplasia. The pre-operation CT scan showed right thyroid large nodule with heterogonous enhancement...

ea0017p14 | (1) | BSPED2008

Growth and pubertal status following pubertal induction in boys with IBD

Mason A , Wong S , Russell R , McGrogan P , Ahmed S

Background: Children with inflammatory bowel disease (IBD) may suffer from growth and pubertal delay.Objective: To assess pubertal status and growth in a group of boys with IBD before (T+0) and 6 months after (T+6) initiation of testosterone therapy.Methods: Retrospective study of boys with IBD undergoing pubertal induction. Height (Ht) and pubertal status were obtained at T+0 and T+6. Markers of disease activity and data on concom...

ea0003p24 | Clinical Case Reports | BES2002

Acute polyarticular synovitis complicating Grave's disease

Wong S , Malik I , Huda B , Dewan S , McCrimmon R

INTRODUCTION: Although thyrotoxicosis involving the musculoskeletal system is well described, classically presenting with proximal myopathy, arthralgia and osteopenia, an acute synovio-arthritis is extremely rare. There are only two published case reports, which have features distinct from Rheumatoid, Sjogren's and Psoriatic arthropathy.CASE REPORT: A 21-year-old lady presented with a 2-month history of symptoms and signs consistent with thyrotoxicosis....

ea0085p37 | Obesity 1 | BSPED2022

Obesity in glucocorticoid treated boys with duchenne muscular dystrophy: a need for structured nutritional-metabolic assessment and pro-active management

McCarrison S , MacDonald T , Horrocks I , Mochrie R , Joseph S , Wong SC

Background: Glucocorticoid (GC) therapy is standard of care of management of Duchenne Muscular Dystrophy (DMD) but its use is associated with a range of side-effects. Weight gain leading to significant obesity is common in GC-treated boys.Aim(s): To evaluate changes in growth parameters: height-SDS, weight-SDS, body mass index (BMI)-SDS following initiation of GC in DMD.Methods: Between 2013-2019, 26 boys with DMD were commenced on...

ea0039oc6.4 | Oral Communications 6 | BSPED2015

Associated renal anomalies in children with Turner syndrome: 43-year experience from a single-centre

Lucaccioni Laura , Wong S C , Strano Rosario , Donaldson Malcolm , Cascio Salvatore , Mason Avril

Objective: To assess prevalence, clinical features, and follow-up of renal/urological malformations in patients with Turner syndrome (TS).Methods: The medical records of 182 patients with TS born between 1970 and 2013 were retrospectively reviewed.Results: Twenty-one girls (11.5%) were identified with renal/urological anomalies: 15 (71%) horseshoe kidney (HSK), 1 (4.7%) malrotation, 2 (9.5%) single kidney, and 1 (4.7%) duplex colle...