ea0049oc1.1 | Adrenal-Basic & Clinical | ECE2017
Kunzke Thomas
, Sun Na
, Sbiera Silviu
, Wild Vanessa
, Aichler Michaela
, Ronchi Cristina
, Schlegel Nicolas
, Rosenwald Andreas
, Fassnacht Martin
, Walch Axel
, Kroiss Matthias
Adrenocortical carcinoma (ACC) is an orphan tumor entity the pathogenesis of which is poorly understood. In advanced tumour stages, prognosis is unfavorable, but biomarkers for early diagnosis are lacking. MALDI-Mass Spectrometry Imaging (MALDI-MSI) enables semi-quantitative detection of a broad spectrum of analytes including endogenous cell metabolites in tissue sections. MALDI-MSI was used as a discovery approach to analyse tissue specimens of 72 ACC patients in FFPE tissue ...