Endocrine Abstracts

Purpose: We found the hypomethylation status of CYP11B2 gene in the aldosterone-producing adenomas compared with normal adrenal glands or non-functioning adrenal adenomas and reported that the methylation of promoter region of this gene influenced the mRNA expression in the adrenal cells. Angiotensin II or potassium regulates CYP11B2 gene expression in the adrenal cells. In order to clarify the acute effect of potassium on the methylation status of CYP11B2 gene, Human adrenal ...