Endocrine Abstracts

Carney complex is a rare hereditary syndrome with an autosomal dominant inheritance pattern that manifests itself with a set of specific symptoms. Case presentation. 32-year-old woman was admitted to the endocrinological hospital with an active stage of acromegaly. From the anamnesis it is known that at the age of 11, the height was 172 cm. The diagnosis of acromegaly was established at the age of 28 years: IGF-1 673.8 ng/ml (78–311), pituitary gland with para(d)-sellar s...

Background: Acromegaly is an orphan neuroendocrine disease characterized by a variety of complications. Due to slow symptom progression acromegalic patients often are involved in growth hormone complications correction for a long time instead of search for main cause of these multiple disorders. A view on conductive hearing loss in acromegaly in literature is contradictory. The low incidence of hearing in acromegaly, compared with other complications, is presumably due to the ...

Background: Acromegaly is a neuroendocrine disease that occurs with slowly progressive symptoms, which leads to delayed diagnosis and the development of complications. Arthropathy is one of such complications, which is accompanied by severe pain and significantly worsens the quality of life. The main attention of researchers is devoted to the pathology of the hip, knee and hand joints. At the same time, the study of the shoulder, acromioclavicular, costovertebral joints in acr...

Background: Acromegaly is a chronic endocrine disease characterized by excessive secretion of somatotropic hormone (GH), which in turn leads to increased secretion of insulin-like growth factor 1 (IGF-1) in the liver. Many cells in the body are targets for these hormones. Excess of GH, in the vast majority of cases caused by hormone-producing pituitary adenoma, and IGF-1 leads to cellular and tissue growth of practically all organs and systems, including the bone and joint app...

Background: The combination of various endocrine tumours is presented both as hereditary syndromes and sporadic forms. Medullary thyroid cancer and prolactinoma are neuroendocrine tumours, the presence of these two pathologies simultaneously has not been previously described in the literature.Objective: To present a clinical case of a patient with giant prolactinoma and medullary thyroid cancer.Materials and Methods: To describe th...

Background: One of the complications of hypothyroidism is the disorder of the neuromuscular system. Myopathic changes often accompany hypothyroidism and are observed in 30-80% of patients. A distinctive feature of hypothyroid myopathies is the reversibility of clinical manifestations and significant improvement of well-being after levothyroxine compensation of the disease. However, the absence of a vivid clinical picture of hypothyroidism, combined with its rare occurrence, co...