Endocrine Abstracts

Melatonin inhibits vascular smooth muscle cell proliferation and apoptosis through upregulation of Sestrin2Excessive vascular smooth muscle cell (VSMC) proliferation contributes to the development of atherosclerosis and restenosis. On the other hand, apoptosis of VSMCs accelerates plaque rupture in the atherosclerotic vessels. Therefore, a strategy that regulates both VSMC proliferation and apoptosis is essential for the development of new pharmacologica...

Pathological proliferation and migration of vascular smooth muscle cells (VSMCs) has been implicated in the pathogenesis of accelerated atherosclerosis in patients with diabetes mellitus. Increased aerobic glycolysis is a key feature of cellular phenotypes including cancer and immune cells. However, it remains largely unknown about the role of aerobic glycolysis in atherogenic phenotype of VSMCs. Here, we investigated the role of lactate dehydrogenase-A (LDH-A), which is a key...

Objective: Hypoglycemia is a common adverse event and one of the main obstacles to achieving good glycemic control to minimize the risk of diabetic complications in patients with diabetes. Therefore, most physicians try to reduce hypoglycemia events through education about hypoglycaemia, such as diabetes self-management education. In this study, we surveyed the actual insight about hypoglycemia, behavior of diabetic patients to avoid hypoglycemia and the fear of hypoglycemia.<...

Proprotein convertase subtilisin/kexin type 9 (PCSK9), a circulating protein that promotes degradation of the low density lipoprotein (LDL) receptor, has been emerged as a novel therapeutic target for the dyslipidemia. It is well known that the pathogenesis of cardiovascular disease (CVD) involves lipid metabolism alteration, but the predictive value of circulating PCSK9 level concerning coronary disease severity is largely unknown. The main objective of this study is to deter...

Pyruvate dehydrogenase kinase 4 (PDK4) activation is associated with metabolic diseases including hyperglycemia, insulin resistance, allergies, and cancer. We report here a new series of allosteric PDK4 inhibitor modified from hit anthraquinone. A novel PDK4 inhibitor, namely compound 8c, improved glucose tolerance in diet-induced obese mice. PDH activity in muscle and liver was enhance d by compound 8c treatment. Given the importance of PDK4 in immune cells including mast cel...

Renal tubulointerstitial fibrosis is a common feature of the final stage of nearly all cause types of chronic kidney disease. Although classic peroxisome proliferator-activated receptor-gamma (PPARγ) agonists have a protective effect on diabetic nephropathy, much less is known about their direct effects in renal fibrosis. This study aimed to investigate possible beneficial effects of lobeglitazone, a novel PPARγ agonist, on renal fibrosis in mice with unilateral uret...

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Aims: High level of uric acid is known to associate with stroke, coronary artery disease and metabolic syndrome. Some epidemiologic studies suggested that high uric acid level is connected with dyslipidemia. However, this relationship was not examined in type 2 diabetic patients. This study was conducted to investigate the association between serum uric acid level and lipid profiles in type 2 diabetic patients.Methods: A total of 972 type 2 diabetes pati...

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