ea0029s28.1 | Osteoporosis treatment in 2012 and beyond | ICEECE2012
Papapoulos S.
Bisphosphonates, because of their efficacy, safety and ease of administration, are accepted as first-line therapy for osteoporosis worldwide. They decrease the rate of bone resorption but have also distinct pharmacological properties including preferential uptake in the skeleton, primarily at sites with increased bone remodeling, and long-term retention in bone. There are differences among bisphosphonates both in their affinity for bone as well as in their antiresorptive poten...