ea0049gp223 | Thyroid 3 | ECE2017
Bellusci Lorenza
, Sabatini Martina
, Nesi Giulia
, Rapposelli Simona
, Rossi Leonardo
, Lenzi Paola
, Fornai Francesco
, Zucchi Riccardo
, Chiellini Grazia
Endogenous TH metabolite 3-iodothyronamine (T1AM) and recently developed thyronamine-like synthetic analogues SG1 and SG2 have emerged as neuroprotective agents. Autophagy has proved to be an effective therapeutic approach for neurodegenerative diseases. Therefore we investigated whether these compounds can induce autophagy in human glioblastoma cells (U-87MG).Cultured U-87MG cells were initially treated with 1 μM T1AM, SG-1, SG-2 or vehicle for 30&...