ea0049ep932 | Pituitary - Basic | ECE2017
Weigand Isabel
, Knobloch Lisanne
, Vanselow Jens T.
, Flitsch Jorg
, Monoranu Carmelia M
, Saeger Wolfgang
, Hagel Christian
, Herterich Sabine
, Ronchi Cristina
, Schlosser Andreas
, Fassnacht Martin
, Deutschbein Timo
, Sbiera Silviu
Recently, somatic, heterozygous mutations in the gene encoding the deubiquitinase USP8 have been identified in 3060% of corticotroph tumors. These mutations were found to hinder binding of 14-3-3 proteins, increasing its deubiquitinating activity. One substrate is Epidermal Growth Factor Receptor (EGFR), USP8 triggering EGFR recycling and increased EGFR signaling. However, tumors harboring mutations in USP8 are smaller than WT tumors, raising the debate if EGFR, as a pot...