Endocrine Abstracts

Background and study aims: Increased aldosterone production in the adrenal gland plays a role in many hypertensive patients. Structural changes of the zona glomerulosa with age in normotensive patients have been described in literature but the influence of aging on aldosterone secretion and physiology is unclear. The aim of this study is to investigate changes in the ZG in order to gain insight in the origin, development and definition of aldosterone producing cell clusters (A...

Introduction & Objectives: A laparoscopic radical adrenalectomy is the standard treatment option for unilateral primary aldosteronism. Partial adrenalectomy for solitary adenomas has been suggested to be feasible and adrenal cortex-sparing. However, solitary adenomas may be rare. The purpose of this study was to assess whether partial adrenalectomy in patients with a seemingly solitary adenoma might be worthwhile by relating perioperative imaging to pathologic findings of ...

Background: Tumor-associated macrophages (TAMs) with dysregulated inflammatory phenotypes play a key role in carcinogenesis. In thyroid carcinoma (TC), excessive release of proinflammatory cytokines decreases the expression of sodium-iodine transporter and inflammation potentiates tumor progression.Aim: To assess the impact of TC cells on the functional reprograming of TC-induced macrophages at the level of transcriptome and metabolic pathways, and asses...

Recent studies have reported a high prevalence of USP8 mutations in corticotroph adenomas causing Cushing’s disease. Nelson’s syndrome is a potentially life-threatening complication of bilateral adrenalectomy in patients with refractory Cushing’s disease that is caused by the development of an ACTH-secreting tumor in the pituitary gland. Whether USP8 alterations are also present in Nelson’s tumors has not been studied in detail so far....