Endocrine Abstracts

Aim: The aim of our study was to assess the contribution of genetic variation in some previously reported gestational diabetes mellitus (GDM) susceptibility loci and lifestyle parameters to GDM risk.Methods: We performed a case-control study of 278 GDM cases and 179 controls who had filled up special questionnaires concerning their lifestyle habits during the oral glucose tolerance test (OGTT) on the 24–32 week of gestation. The questionnaire consis...

Purpose: D631Y is a rare mutation associated with MEN2a in which there is an aspartic acid to tyrosine amino acid substitution at codon 631 in exon 11. Common clinical features of this variant of RET mutation are pheochromocytoma in 50%, medullary carcinoma in 30%, primary hyperparathyroidism is very rare. We present the patient harboring RET D631Y mutation.Clinical case: In April 2017 40-year-old woman was admitted to endocrine department of the Almazov...

Background: Understanding the mechanism whereby the intrauterine hyperglycemia in women with gestational diabetes mellitus (GDM) affects the offspring’ predisposition to metabolic and cardiovascular diseases may help prevent their intergenerational transmission. Our aim was to study the effect of the degree and duration of maternal hyperglycemia on the level of expression of genes associated with cardio-metabolic diseases in human umbilical vein endothelial cells (HUVECs)...