Endocrine Abstracts

Introduction: Hyponatremia is the most common disorder of electrolytes encountered in clinical practice, occurring in up to 15–30% of both acutely and chronically hospitalized patients. Although most cases are mild and relatively asymptomatic, it is important clinically because: i) acute severe hyponatremia can cause substantial morbidity and mortality, ii) mortality is higher in patients with hyponatremia who have a wide range of underlying diseases and iii) overly rapid...

Introduction: The adverse impact of overt hypothyroidism that complicates pregnancy outcomes is well-established. In order to eliminate these complications has long been discussion about the need for early detection of the disease of the thyroid gland in the population of women planning pregnancy, respectively in early pregnancy. In Slovakia, this effort resulted in the approval of screening for thyroid diseases in pregnancy and has been enshrined in a legislative in 2009. Obl...

The presence of pheochromocytoma/paraganglioma can be characterized by typical clinical signs, due to hemodynamic and metabolic activity of circulating catecholamines or less a consequence of other amines or neuropeptides produced simultaneously. But the clinical picture can be also very different and can play a clinical picture of other diseases.The authors present a case report from a patient with retroperitoneal paraganglioma. The patient was admitted...

Background: Pituitary prolactin secretion is physiologically supressed by dopaminergic tonus from hypothalamus, which itself is under regulation by various hypothalamic releasing factors. We Disturbed dopaminergic tonus in patients with liver cirrhosis is suspected.The aim of our study was to measure prolactin levels in patients with cirrhosis and to investigate the relatioship between the severity of liver disease and other clinical and laboratory param...

There have been many discussions about testosterone role in inflammation and autoimmunity. Inflammatory bowel disease (IBD) is a chronic autoimmune disease in younger age groups. The aim ouf our study was to evaluate testosterone concentration and it’s influence on disease acitivity and the quality of life.In our cross-sectional study we measured total testosterone levels in males with IBD (Crohn’s Disease, Ulcerative colitis). Age, BMI, main c...

Background: Hyponatremia is the most common electrolyte abnormality, it increases morbidity and mortality, but it is not clear if this condition influences mortality independently of other contributing factors. The aim of our study was to assess the relative contribution of hyponatremia to in-hospital mortality and to determine predictive factors associated with hyponatremia-related mortality.Materials and methods: A database search was conducted for all...

Background: Thyroid-stimulating hormone (TSH) might influence bone mineral density (BMD) through its regulation of the thyroid hormones thyroxine (T4) and triiodthyronine (T3). Direct effect of TSH on bone turnover, mediated through its receptors on both osteoblast and osteoclast precursors, has been suggested. We wanted to explore the relationship between serum TSH, fT4 and BMD in women with different TSH levels after a long-term observation of thyroid function and bone statu...

Introduction: Impaired fertility in women with Crohn’s disease compared to healthy women seems to be a consequence of Crohn’s disease, according to older studies. However, data are not consistent, and it is not clear why could the reduced fertility occur. Influence on ovarian reserve might be one of the answers.Patients: The study group consisted of women with Crohn’s disease. The control group consisted of age and BMI matched healthy wome...

Introduction: Effective identification, diagnosis and management of growth hormone (GH) deficiency in adults are crucial for treating endocrinologists to provide the best in patient care. As such, it is important that we share our experiences to understand challenges and obstacles to enhance the patient journey. The objective of this project was to start identifying these challenges and obstacles.Methods and findings: In November 2016, an expert panel of...