Endocrine Abstracts

Introduction: The classical role on calcium homeostasis played by vitamin D is well documented. Lately vitamin D is linked to a variety of chronic diseases related to ageing, diabetes, and cardiovascular diseases. However, the pathophysiological roles of vitamin D in such cases are unclear.Aim: To clarify the relation of metabolic syndrome (MS), testosterone levels, and vitamin D status in men.Patients and methods: 99 male patients...

Aim: Netrin is classically recognized as a neural guidance cue that has been involved in various tissues including pancreas development. Because of Netrin’s tissue regenerative, angiogenic, and inflammatory suppression properties it could play a crucial role in the development of insulin resistance and type 2 diabetes. The aim of the current study is to investigate the relation between circulating levels of Netrin-1 and the glucose continuum.Method...

Aims: Irisin is a recently discovered myokine that has been implicated in the pathogenesis of type 2 diabetes (T2D) and metabolic syndrome (MS). Its involvement with cardiovascular disease (CVD), however, has not yet been elucidated. The aim of the current study was to shed light on the potential association with irisin and cardiovascular risk.Methods: Eighty patients with obesity (BMI ≥ 30 kg/m2) and mean age 50,4±10,6 years were i...

Apelin is a new adipokine associated with obesity. Data about the relationship of apelin to the metabolic syndrome (MS) are still scarce. Late-onset hypogonadism (LOH) is common in men with MS, but we did not find data about the levels of apelin in men with LOH.The aim of this study was to determine the levels of apelin in men with MS with or without LOH.Patients and methods: Ninety nine men were included in the study. Of them 65 h...

Introduction: OSA is a rare condition in premenopausal women that do not have PCOS and is most frequently associated with obesity. On the other hand the risk in PCOS patients is thought to be significantly higher. The aim of the study was to investigate the prevalence of sleep apnea in Bulgarian patients with PCOS and/or obesity.Methods: The study included 30 women – 11 obese, 13 nonobese PCOS and six obese PCOS patients. Anthropome...

Background: Chronic low-grade inflammation is a major factor in the pathogenesis of type 2 diabetes. One way for promoting inflammatory cytokines secretion is through activation of toll-like receptors (TLR). Their overexpression on monocytes has been demonstrated in insulin resistance and type 2 diabetes. Soluble forms of toll-like receptors (sTLR) are considered a regulatory mechanisms of their activation. Their role has been described in modulation of bacteria-induced infect...

Objective: The beneficial effects of testosterone replacement therapy (TRT) in men with hypogonadism on the body composition and metabolic parametersare well-established, but the intimate mechanisms of these effects are not fully understood. Resistin is a small protein that is involved in the regulation of glucose metabolism and is considered to be key in the development of insulin resistance and to induce proinflammatory effects. We hypothesize that TRT has an impact on the a...

BackgroundBoth obesity and diabetes are associated with chronic low-grade inflammation. IL-18 is a cytokine that stimulates various cell types and has pleiotropic functions. The aim of the present study was to investigate the circulating levels of IL-18 in different stages of glucose dysregulation from obesity through prediabetes to newly diagnosed diabetesMethodsIL-18 levels were determined using a commercia...

Primary hyperparathyroidism (PHPT) is being more and more frequently diagnosed.Objectiveto describe the clinical presentation and the main laboratory and imaging findings in a group of patients with PHPT diagnosed during the last 10 years. Materials and Methods: This was a retrospective cross-sectional study with data review from the last 10 years. Secondary causes for elevated PTH were excluded. The symptoms and signs of hypercalc...

Background: Retinol-binding protein 4 (RBP4) is known as an acute phase inflammatory reactant, associated with insulin resistance. Increased levels of this novel adipokine is observed in obesity, type 2 diabetes mellitus, metabolic syndrome (MetS) and cardiovascular diseases, as well as in nonalcoholic fatty liver disease (NAFLD), but some of these data remain controversial. The aim of this study was to evaluate the relationship between RBP4 and prediabetes in...