Endocrine Abstracts

Introduction: Rare cases of pheochromocytoma are associated with stress induced Takotsubo cardiomyopathy explained by high catecholamine exposure causing microvascular spasm and direct myocardial impact.Case report: A 49-year-old female with a history of poorly controlled hypertension, with paroxysmal elevations in blood pressure and rare supraventricular extrasystoles, lipothymic events, was firstly assessed in the cardiologic department. She presented ...

Resistance to thyroid hormones (RTH) is a genetic syndrome characterized by reduced responsiveness of target tissues to thyroid hormones (TH) and accompanied by normal or slightly high TSH values with high serum concentrations of fT4 or fT3. We present two cases of RTH, one pituitary and one generalised resistance.Case 1: A 31 y.o. male presented with thyrotoxicosis symptoms and a biochemical profile showing increased serum fT4...

A 42-years woman presented with hypothyroidism, a large, firm, irregular goiter, severe cervical and preauricular pain, 2 weeks after an episode of respiratory infection. Laboratory findings certified subacute thyroiditis and autoimmune hypothyrodism: TSH>50 μUI/ml, FT4=6.5 pmol/l, ATPO>1000 U/ml, ATGL>1000 U/ml, ESR=115 mm/1 h. Thyroid ultrasound showed hypoechogenic pattern with a nodule on the right lobe and low Doppler signal. Fine needle aspira...

Adrenal carcinoma is a very rare malignancy accounting for 0.05–0.2% of all cancers, with an incidence 0.5–2/106.We present the case of a 60 year old woman with impaired fasting glucose and hypertension, who was incidentally diagnosed, after a non-enhanced abdominal CT, with a right adrenal tumor of 4.5/6 cm. The mass was described as having smooth borders, and a heterogeneous aspect including solid parts, necrotic areas and 1 microc...

Giant prolactinomas are rare pituitary tumors, defined as adenomas greater than 4 cm, with extrasellar extension, presenting with PRL levels > 1000 ng/dl. Dopamine agonists (DA) are the first-line treatment. Most (90%) of giant prolactinomas occur in men.We describe two cases of giant prolactinoma. A 17 years man presented with frontal headache, gradual visual deficit, nausea and dizziness. MRI demonstrated a sellar tumor of 6.4 cm with extrasellar e...

Introduction: Von Hippel-Lindau (VHL) disease is an inherited, autosomal dominant syndrome manifested by a variety of benign and malignant tumors, with an incidence of about 1 in 36 000 individuals and a mean age at presentation of 26 years.We present a family (mother and daughter) case of possible type 2A VHL disease diagnosed with multiple VHL-associated tumors in the absence of an available genetic testing. They both presented in our clinic in 2013 wi...

Background: Parathyroid carcinoma (PC) is a rare cause of primary hyperparathyroidism (PHPT), accounting for <1%, with an equal gender distribution and an average age of diagnosis in the fifth decade of life. The diagnosis of PHPT is based on the laboratory finding of high levels of immunoreactive PTH in the presence of severe hypercalcaemia. The only potentially curative treatment for PC is surgery. Early surgery is the most important factor for optimal outcome.<p cla...

Adrenal cortical carcinoma is a rare disease with an incidence of 1–2/million per year. Diagnosis is related to autonomy of adrenal steroid synthesis, tumour size above 6 cm, local invasion and tendency to recurrence. Treatment consists in adrenal surgery, non-specific chemotherapy and radiotherapy, and, more specific-Mitotane (Lysodren).Pathology diagnosis is based on capsular and vascular invasion, histological changes suggestive for malignancy an...

Generously supported by IPSEN)-->Treatment with hormone analogues can challenge the precise measurement by interference with the routinely used immunoassays systems, related to the presence of autoantibodies in the serum, interference with associated therapy or the presence of altered forms of the hormone, with modified biological activity and/or immunoreactivity.In patients with acromegaly treated with the hGH...

Objective: To study the role of the GnRH analogue Triptorelin in the assessment of the hypothalamic-pituitary-gonadal axis, in guiding therapy for infertility and identifying hypogonadic patients with recovery potential (functional hypothalamic dysfunction and idiopathic hypogonadotropic hypogonadism).Methods: Dynamic testing using subcutaneous injection of 100 μg Triptorelin was performed in 29 adults (11 women) with hypogonadotropic hypogonadism (...