Endocrine Abstracts

Introduction: Multisystem Langerhans cell histiocytosis (LCH) is a rare heterogeneous disorder caused by accumulation in multiple organs of dendritic cells phenotypically similar to cutaneous Langerhans cells. Pituitary involvement is present in about 25% of cases, and central diabetes insipidus is the most common deficit in that setting. Panhypopituitarism is rare, but hypothalamic-pituitary dysfunction is amongst the most frequent long-term complications of the disease.<...

Introduction: Ectopic posterior pituitary (EPP) is a neuroimaging diagnosis frequently identified together with other hypothalamo-pituitary (H-P) abnormalities [hypoplastic anterior pituitary and thin interrupted stalk -Pituitary Stalk Interruption Syndrome (PSIS)] and associated with variable endocrine phenotypes evolving over time. We aim to describe the spectrum of hormonal deficiencies and neuroimaging abnormalities in a large cohort of children with EPP.<p class="abst...