ea0049gp28 | Adrenal 3 | ECE2017
Espiard Stephanie
, Knape Matthias
, Bathon Kerstin
, Assie Guillaume
, Abid Daniel
, Faillot Simon
, Calebiro Davide
, Herberg Friedrich
, Stratakis Constantine
, Bertherat Jerome
Introduction: Alterations of the cAMP signaling pathway are described in adrenal tumors causing Cushing syndrome, specifically mutations in the gene coding for the protein kinase A (PKA) catalytic subunit alpha (PRAKCA) in cortisol producing adenomas (CPA) with overt Cushing syndrome.Materiel and Methods: Eight CPAs without PRKACA mutations were analyzed by whole exome sequencing. Direct sequencing of PRAKCB encoding for the catalytic subunit beta (C^...