ea0049gp2 | Adrenal 1 | ECE2017
El Zein Rami
, Rickard Amanda J
, Felipe Golib Dzib Jose
, Samson-Couterie Benoit
, Rocha Angelique
, Poglitsch Marko
, Gomez-Sanchez Celso E
, Amar Laurence
, Fernandes-Rosa Fabio Luiz
, Ghyselinck Norbert B
, Benecke Arndt
, Lalli Enzo
, Zennaro Maria-Christina
, Boulkroun Sheerazed
Recurrent somatic mutations in KCNJ5, CACNA1D, ATP1A1 and ATP2B3 have been identified in aldosterone producing adenoma (APA). Although the role of these mutations in regulating aldosterone biosynthesis has been clearly established, the mechanisms involved in proliferation and APA formation still remain to be elucidated. The aim of our study was to identify pathways involved in adrenal cortex nodulation and APA formation.Transcriptomic a...