Endocrine Abstracts

Introduction: Pheochromocytoma is extremely rare in pregnancy and occurs 1 in 54000 pregnancies. If undiagnosed, Maternal and fetal mortality amounts to 40–50%. Early detection and prompt treatment decreases the maternal and fetal mortality to <5% and <15% respectively. There are multiple and complex issues in managing this condition in pregnancy. We would like to present such a case with very good outcome.Case: 28-year-old woman was admitte...

Introduction: Vitamin D deficiency occurs more frequently in patients with primary hyperparathyroidism compared to general population, and is usually associated with an aggravated form of the disease. Current guidelines recommend measurement of vitamin D level in all patients with primary hyperparathyroidism, and their repletion if the levels are <50 nmol/l.Case report: We present a 56 years old Caucasian lady who underwent right parathyroidectomy &#...

75 male was referred to endocrine service with incidental pituitary macroadenoma measuring 4.2×3.1×3.3 cm noted on MRI-C-Spine done for ankylosing spondylitis with Atlanto-axial joint instability. He had reduced secondary sexual characteristics and left quadrantanopia. Endocrine studies confirmed thyrotroph and gonadotroph failure but normal lactotroph and HPA axis. He underwent trans-sphenoidal tumour resection followed by external beam radiation due to tumour resid...

Introduction: We submit a rare presentation of pheaochromocytoma in pregnanacy, diagnosed just before delivery, posing complex management difficulties.Case presentationA 24-year-old primipara had headache, hypertension and visual disturbance but without any palpitations or diaphoresis. Her headache was persistent during pregnancy. Investigations at 39 weeks of gestation showed normal plasma Normetadrenaline at 885.0 (120–1180)...

Introduction: Graves’ thyrotoxicosis and Addison’s disease are disorders with a strong auto-immune basis. Primary hypothyroidism and Addison’s disease are recognised components of polyglandular autoimmune syndrome type II (PGA-II). Despite its autoimmune etiology, Graves disease is not commonly associated with PGA-II. We present a case of a patient with newly diagnosed Graves’ disease presenting in incipient adrenal crisis due to unrecognized Addison’s...

Introduction: Non-islet cell tumour hypoglycaemia (NICTH) is an uncommon but serious complication of disseminated malignancy. The underlying aetiology of hypoglycaemia is tumoral overproduction of IGF2, which results in stimulation of insulin receptors and increased glucose utilization. Extensive tumour burden involving the liver and adrenal glands can also cause severe hypoglycaemia.Case report: An 80-year-old man presented acutely in an unresponsive st...

Introduction: Hypothalamic–pituitary sarcoidosis is uncommon and affects <10% of patients with neurosarcoidosis. It presents a diagnostic challenge. We present a case of isolated central hypoadrenalism presenting as the sole manifestation of neurosarcoidosis.Case history: A 76-year-old man with recently diagnosed primary hypothyroidism presented with weight loss, increasing lethargy and fatigue. Physical exam revealed inguinal lymhadenopathy. St...

Gonadotroph pituitary adenomas are common but majority of them are classified as non-functional as they do not lead to features of hormonal excess. Functional gonadotroph adenomas are rare and there are only few small series or individual case reports about these.Case report: 45-year-old gentleman presented with headaches, progressive visual failure and complaint of excessive tiredness. He had normal libido and had an 8-year-old child. On examination, he...

Introduction: We submit a rare presentation of round blue cell pituitary tumour complicated by cranial diabetes insipidus following transphenoidal surgery.Case history: 47-year-old lady with severe headache was diagnosed with a 10 mm non functioning pituitary macro adenoma. Initial plan for conservative management was revised as she developed sixth cranial nerve palsy, bi temporal hemianopia and rapidly enlarging pituitary tumour to 20×18×19 mm...